Cancer stem cells (CSCs) are a subpopulation of cancer cells endowed with high tumorigenic, chemoresistant and metastatic potential. Nongenetic mechanisms of acquired resistance are increasingly being discovered, but molecular insights into the evolution
EVs actively participate in cell-to-cell interactions by shutting cellular components.153There was strong evidence that CSCs-derived EVs promoted non-CSCs to acquire stem-like properties, leading to the enhanced tumorigenicity.153,154,155,156Studies have found that EVs shed by CSCs carry the stemn...
Cancer stem cell (CSC) markers could serve as potential prognostic procedure. This study is aimed to investigate the local expression of doublecortin-like kinase 1 (DCLK1) and Lgr5 in colorectal cancer tissues (CRC) at both protein and messenger RNA (mRNA) level, followed by providing a compa...
Aldehyde dehydrogenase 1A1, Angiogenesis, Breast cancer cells, Stemness, Vascular endothelial growth factorBackground Aldehyde dehydrogenase 1A1 (ALDH1A1), a member of aldehyde dehydrogenase family, is a marker of stemness in breast cancer. During tumor progression cancer stem cells (CSCs) have ...
Nanoparticles for targeted drug delivery to cancer stem cells: a review of recent advances. Nanomaterials. 2021;11(7):1755. Article CAS PubMed PubMed Central Google Scholar Plaks V, Kong N, Werb Z. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor ...
6. Glycolysis deviation to PPP: from cancer cell to cancer stem cell 7. Dual effects of ROS on HIF-1 8. Possible mechanisms of glycolysis deviation to PPP 9. In response to increased ROS, which one do the cancer cells increase? PPP or other pathways of NADPH production 10. Conclusion Co...
Cell Adhesion, Invasion, and Metastasis MT1-MMP/MMP-14 14552-1-AP MMP-1 10371-2-AP MMP-9 10375-2-AP Cell Stemness Nanog 14295-1-AP ALDH1 15910-1-AP OCT4 11263-1-AP Angiogenesis VEGF 19003-1-AP IHC Kits for Cervical Cancer Research ...
these two stem markers expressed differently in different subtypes of breast cancer, and had different functions in tumor progression. High CD44/CD24 ratio was more related to cell proliferation and tumorigenesis, while ALDH1+was a stronger indicator for metastasis. Single CSC marker alone can not ...
11 The microbiota can affect EMT and enhance the expression of cancer stem cell (CSC) markers. Bessède et al. reported that infection with H. Pylori CagA-positive strain triggers EMT-like changes and high expression of CD44 in vitro, a known gastric CSC marker, leading to an enhanced ...
[52], they separated the renal tumor cells and used the mesenchymal stem cell marker CD105 from human renal carcinomas. Afterwards, they found that CD105+cells but not CD105−cells have the proficiency of differentiation into vWF/KDR/VEGFR3/CD31 positive endothelial cells in vitro; moreover...