近日,比利时VIB-KU鲁汶癌症生物学中心的研究团队在《Cancer Research》上发表了题为“Fat induces glucose metabolism in non-transformed liver cells and promotes liver tumorigenesis”的文章。该研究发现正常非癌性肝细胞接触大量脂肪后将采取与癌细胞相似的代谢方式,长期高脂肪饮食很可能导致肝细胞癌变,这一发现将饮...
In particular, FAT10 has a higher affinity for the phosphorylated form of ABI3 than the non-phosphorylated form, and it stabilizes the phosphorylated form more than the non-phosphorylated form through this differential affinity. The interaction between FAT10 and the phosphorylated form of ABI3 ...
Collective cancer invasion with leader–follower organization is increasingly recognized as a predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by creating invasion tracks, sensing environmental cues and coordinating w
2024年5月30日,中山大学苏士成团队在Cancer Cell在线发表题为“Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite”的研究论文,该研究分析了接受曲妥珠单抗和抗PD- L1抗体治疗的HER2+ 乳腺癌患者肿瘤的多组学数据,发现CNS富...
Origin recognition complex 6 overexpression promotes growth of glioma cells Wen-lei Yang , Wei-feng Zhang & Jun Zhu Article 21 June 2024 | Open Access Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization Chunming Xu , Jie...
The tumor microenvironment (TME) is an important factor that regulates the progression of colorectal cancer (CRC). Cancer-associated fibroblasts (CAFs) are the main mesenchymal cells in the TME and play a vital role in tumor progression; however, the spe
Notably, the deletion of FOXA1 and FOXA2 in mouse embryonic livers results in the proliferation of biliary ductal cells, as FOXA1/2 prevents biliary ductal cells from overproliferation to maintain normal bile duct development [18]. Furthermore, FOXA1 can combine with three other transcription ...
Cancer cells. Credit: Dr. Cecil Fox, National Cancer Institute A switch in fat metabolism from production to import could be exploited for cancer treatment, researchers say. Knowing whatcancerwill do next could lessen the likelihood of it becoming resistant to treatment. A new University of Toront...
(EV's) enriched in harmful and inflammatory molecules into the blood stream, which can alter breast cancer cells to become more aggressive and invasive. These findings suggest that substances released from fat tissue may increase tumor malignancy that could lead to new therapeutic targets and ...
fat cells are now understood to be active cells that produce more than 400 adipokines (hormones) which eventually end up in the blood and make their way around the body. Connor and his research team set out to determine whether the hormones found inbody fatcan account for the observed...