Fibroinflammation, a highly integrated fibrogenic and inflammatory response, is activated in response to tissue perturbation and thus contributes to tumour initiation, growth and metastasis. Here, Xiao and Puré outline the complexity of cancer-associated fibroinflammation and provide insights into its ther...
Cancer metabolism refers to the alterations in cellular metabolism pathways that are evident in cancer cells compared with most normal tissue cells. Metabolic alterations in cancer cells are numerous and include aerobic glycolysis, reduced oxidative phosphorylation and the increased generation of biosynthetic...
The poison injected into her veins reduced her jaw muscles to scar tissue so she could barely open her mouth to talk. Chewing food was out of the question so she was reduced to a liquid diet and we began bringing her smoothies. My mom was able to return home shortly after chemotherapy t...
The rib cage is an arrangement of bones in the thorax of all vertebrates except the lamprey and the frog. (图片来源:Bing) bruise Br. [bru:z] Am. [bruz] 瘀伤,青肿 A bruise, or contusion, is a type of hematoma of tissue in which capillaries and someti...
Fat tissue increases the proliferation of MCF-7 cells in vitro. Our data suggest that lipoaspirates as well as DAF might possess a considerable potency to promote tumorigenic growth of breast cancer cells. Thus, clinical trials are needed to address the safety of lipofilling by breast reconstructi...
S1c). We noted that, according to the histopathological data accompanying each GTEx specimen, the adult breast tissue samples showed considerable heterogeneity in cellular composition (e.g., “90% fibrous stroma” vs. “> 90% fat”), and we suspected that the percentage of adipose tissue ...
Matrixattachment regions can impart position- independent regulation of a tissue-specific gene in transgenic mice.Proc Natl Acad Sci USA 1992; 89: 6943–6947. PubMed CAS Google Scholar References Cubilla AL, Fitzgerald PJ. Morphological lesions associated with human primary invasive nonendocrine ...
mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible, efficient and cost-effective tissue studies. This technique has immediate potential for translational research and clinical practice, particularly in the era of cancer immunotherapy. 常规免疫组织...
tissue-resident stem cells, or their progeny [18,19]. Only the CSC population can initiate tumor growth in tumors generated from CSCs, resulting in a unidirectional hierarchy. To maintain their pool of CSCs, CSCs divide asymmetrically at tumor initiation. Transient amplifying cells are generated fr...
MAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important clinical implications. Oestrogen-receptor-positive (ER+) BCa requires oestrogen for both growth and metastasis, albeit by ill-known mechanisms. Here we integrate...