CancerCannabinoidReceptorPainInflammationEvidence for the role of the cannabimimetic fatty acid derivatives (CFADs), i.e. anandamide (arachidonoylethanolamide, AEA), 2-arachidonoylglycerol (2-AG) and palmitoylethanolamide (PEA), in the control of inflammation and of the proliferation of tumor ...
Then, the team isolated cancer cells from the blood and the lymph nodes to better understand why the two behaved differently. Within the membranes of the cancer cells in lymph nodes, the researchers found higher levels of oleic acid, a monounsaturated fatty acid. Their cellular coun...
checkpoint inhibitors in patients with colorectal cancer, lung cancer, hepatocellular carcinoma, or melanoma [80,81,82,83,84,85]. The role of SPP1-expressing TAMs in tumor progression is under intensive investigation. Increased expression of SPP1 predicts poor prognosis in esophageal cancer, colorect...
checkpoint inhibitors in patients with colorectal cancer, lung cancer, hepatocellular carcinoma, or melanoma [80,81,82,83,84,85]. The role of SPP1-expressing TAMs in tumor progression is under intensive investigation. Increased expression of SPP1 predicts poor prognosis in esophageal cancer, colorect...
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and extracellular cholesterol uptake is often elevated in cancer cell to meet its metabolic needs. Tumors take up cholesterol from the blood stream through their vasculature. Breast cancer grows in, and ovarian cancer metastasizes into fatty tissue that provides them with an additional source of chol...
cells. The first thing a healed mitochondria will do in a cancer cell is turn on activation of apoptosis natural cell death. It does this because it notices, once healed, that the cancer cell has lived longer than it is supposed to live. (The mitochondria is the time-keeper of the cell...
Cancer Res. 63, 4547–4551 (2003). CAS PubMed Google Scholar Uematsu, K. et al. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene 22, 7218–7221 (2003). Article CAS PubMed Google Scholar Kikuchi, A. & Yamamoto, H. Tumor ...
at the University of Chicago Biological Sciences Division found that trans-vaccenic acid (TVA) – a long-chain fatty acid in meat and dairy products from grazing animals like cows and sheep – improves the ability of CD8+ T cells in the immune system infiltrate tumors and kill cancer cells....
Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar. Cancer Res 2004;64:7058–7064. 11. Brezillon S, Venteo L, Ramont L, et al. Expression of lumican, a small leucine-rich proteoglycan ...