(Cambridge, MA) announced that it has entered into a research agreement with the University of Arizona Cancer Center (Tucson, AZ) for "Evaluation of Therapeutic Vaccines for Cancer Patients." Evan Hersh, MD, professor of medicine and assistant director of experimental therapeutics and translational ...
(Yonemoto); University of Arizona, Tucson (Breitborde); The University of Hong Kong, Hong Kong, China (Yip); Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada (Pourmalek); Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, ...
In BC, the molecular subtype of the tumor has a major influence on its interaction with the immune system. Triple-negative BC (TNBC) and HER2-positive BC are more frequently infiltrated by higher numbers of TILs than hormone receptor (HR)-positive tumors9,10. However, all BC subtypes include...
Survival from cancer has improved dramatically over the past three decades due to advances in early detection, adjuvant therapeutic strategies, and widespread use of combined treatment modalities including surgery, chemotherapy, and radiotherapy. Unfortunately, these modalities are associated with a spectrum ...
2 Based on responses to questions regarding physical activity level, metabolic equivalent task (MET) in hours per week was computed.20 Body Fat Measurements For 11 393 WHI participants in 3 designated centers (Birmingham, Alabama; Tucson and Phoenix, Arizona; and Pittsburgh, Pennsylvania), body...
College of Public Health, University of Arizona, Tucson, AZ, USA Iman Hakim MD College of Medicine, University of Arizona, Tucson, AZ, USA Linda Garland MD Corresponding author Correspondence to Linda Garland MD . Editor information Editors and Affiliations Arizona Cancer Center, University of Arizo...
Immunohistochemistry (IHC) staining was performed using the Ventana Benchmark XT automated staining system (Ventana Medical Systems, Tucson, AZ, USA) according to the manufacturer’s protocol. For assessing human epidermal receptor 2 (HER2) status, anti-HER2/neu antibody (Clone 4B5; ready to use...
Duplex IHC was performed combining two primary antibodies: HER2 ICD was detected using the monoclonal rabbit antibody clone 4B5 (Ventana Medical Systems, Tucson, AZ), followed by a rabbit-specific streptavidin-biotin–based detection reagent (Zytomed, Berlin, Germany) and visualized by Permanent Red...
In 2016, there was an estimated 1.8 million new cases of cancer diagnosed in the United States. Remarkable advances have been made in cancer therapy and the 5-year survival has increased for most patients affected by malignancy. There are growing numbers
Ring study 3 used a subset of H&E slides from NSABP-B31, an older completed trial evaluating benefit of trastuzumab in early HER2-positive breast cancer, which started accrual in February 2000 across multiple centers. These were excision specimens undergoing local community tissue processing. ...