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Biosystems, Nussloch, Germany), CD20 (1:500, Novocastra Laboratories), and CD79 (1:200, Dako, Agilent Technologies, Santa Clara, CA, USA), using a Ventana ES automated immunohistochemistry (IHC) stainer according to the manufacturer’s protocols (Ventana ES automated IHC stainer, Tucson, AZ,...
Bedogni B, O’Neill MS, Welford SM, Bouley DM, Giaccia AJ, Denko NC, Powell MB (2004) Topical treatment with inhibitors of the phosphatidylinositol 3′-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe co...
14,15. Exploratory subgroup analyses were also conducted by surgery outcome and treatment arm; however, as the responder analysis does not preserve randomization, these results must be interpreted with
Maira SotoUniversity of Arizona Tucson AZ USALeigh NeumayerUniversity of Arizona Tucson AZ USAKathleen E RodgersUniversity of Arizona Tucson AZ USARoberta Diaz BrintonUniversity of Arizona Tucson AZ USAJohn Wiley & Sons, LtdAlzheimer's & Dementia...
(PCR) has a high sensitivity but a low positive predictive value; thus, the diagnosis relies on culture or histopathology [63]. True infection warrants treatment with ganciclovir or foscarnet. Interestingly, increased incidence of co-infection with Nocardia and molds such as Aspergillus has been ...
(Ventana Medical Systems, Tucson, AZ), a single-probe technique that detects single HER2 gene, and the dual-probe (HER2 probe plus chromosome-17 centromere probe) kits, PathVysion™ (Abbott Laboratories, Abbott Park, IL) and PHarmDX (Dako, Glostrup, Denmark).45Previous studies proved that ...
They observed that 63% of patients carrying BRCA1 or BRCA2 mutations who had ovarian, breast or prostate cancer had a clinical benefit from treatment with olaparib with few adverse side effects. This is an example of the concept of “synthetic lethality” which occurs when there is a potent ...
(ISH) for the case with increased lymphocyte infiltration (n = 37) in the test cohort, as previously described28. EBV-encoded small RNA (EBER)-ISH was performed using the INFORM EBER probe (800–2842, Ventana Medical Systems, Tucson, AZ, USA) and the Discovery XT autostainer (Ventana...
Cell lines used in this study were authenticated by short tandem repeat (STR) profiling on Promega PowerPlex16HS Assay at University of Arizona Genetics Core (Tucson, AZ). Cells were grown in DMEM supplemented with 10% FBS and 1% penicillin-streptomycin. They were maintained in a humidified ...