Faculty from six different cancer centers were represented including Memorial Sloan-Kettering Cancer Center, New York, NY, Arizona Cancer Center, Tucson, AZ; Fred Hutchinson Cancer Center, Seattle, WA; Chao Family Comprehensive Cancer Center, Irvine, CA; the Sydney Kimmel Cancer Center, San Diego,...
(Sanabria); Nutrition and Preventive Medicine, Chicago Medical School at Cancer Treatment Centers of America, Rosalind Franklin University, Chicago, Illinois (Sanabria); Nuffield Department of Medicine, Oxford University, Ho Chi Minh City, Vietnam (Beardsley); Department of Global and Community Health...
Some of the most clinically effective chemotherapeutic agents currently used in cancer treatment are DNA damaging agents, and their therapeutic effectiveness appears to often depend on deficient DNA repair in cancer cells. In the next four sections we discuss repair deficiencies in cancer cells that ...
College of Public Health, University of Arizona, Tucson, AZ, USA Iman Hakim MD College of Medicine, University of Arizona, Tucson, AZ, USA Linda Garland MD Corresponding author Correspondence to Linda Garland MD . Editor information Editors and Affiliations Arizona Cancer Center, University of Arizo...
In this multi-center phase II trial, we evaluated the efficacy and safety of a quadruplet regimen (pembrolizumab, trastuzumab, and doublet chemotherapy) as first-line therapy for unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (AGC) (NCT...
Survival from cancer has improved dramatically over the past three decades due to advances in early detection, adjuvant therapeutic strategies, and widespread use of combined treatment modalities including surgery, chemotherapy, and radiotherapy. Unfortunately, these modalities are associated with a spectrum...
Duplex IHC was performed combining two primary antibodies: HER2 ICD was detected using the monoclonal rabbit antibody clone 4B5 (Ventana Medical Systems, Tucson, AZ), followed by a rabbit-specific streptavidin-biotin–based detection reagent (Zytomed, Berlin, Germany) and visualized by Permanent Red...
Design, Setting, and Participants This open-label, phase 3 randomized clinical trial (MYSTIC) was conducted at 203 cancer treatment centers in 17 countries. Patients with treatment-naive, metastatic non–small cell lung cancer who had no sensitizing EGFR or ALK genetic alterations were randomized to...
This study aimed to validate the Clinical Treatment Score post-5 years (CTS5)-based risk stratification in a cohort comprising pre- and postmenopausal patients with estrogen receptor (ER)–positive breast cancer. We investigated the clinicopathologi
value; thus, the diagnosis relies on culture or histopathology [63]. True infection warrants treatment with ganciclovir or foscarnet. Interestingly, increased incidence of co-infection with Nocardia and molds such as Aspergillus has been documented in patients with CMV pneumonia [44]. It is unclear...