Molecular Cancer is delighted to announce its new thematic series: mRNA therapies and mRNA vaccines in cancer Click here to access all thematic series published to date in Molecular Cancer. Featured Article: Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in...
Distinct functions of neutrophil in cancer and its regulation. Mediators Inflamm. 2015, 701067 (2015). PubMed PubMed Central Google Scholar Tecchio, C., Scapini, P., Pizzolo, G. & Cassatella, M. A. On the cytokines produced by human neutrophils in tumors. Semin. Cancer Biol. 23, 159...
et al. SRSF2 is essential for hematopoiesis, and its myelodysplastic syndrome-related mutations dysregulate alternative pre-mRNA splicing. Mol. Cell. Biol. 35, 3071–3082 (2015). CAS PubMed PubMed Central Google Scholar Palangat, M. et al. The splicing factor U2AF1 contributes to cancer ...
However, one analysis of five randomized controlled trials demonstrated that allocation to aspirin reduced the risk of cancer with distant metastases (hazard ratio 0.64, 95% CI 0.48–0.84, p = 0.001), suggesting that patients with cancer may benefit from aspirin and its anti-metastatic ...
and metastasis of many types of cancer, including BC. However, the significance of TNFR2 in BC biology is not fully understood.This reviewprovides an overview of TNFR2 biology, detailing its activation and its interactions with important signaling pathways in the TME (e.g., NF-κB, MAPK, an...
b. When SHH reaches its target cell, it binds to the PTCH1 receptor. The binding of SHH relieves SMO inhibition, leading to activation of the GLI transcription factors. Activated GLI accumulates in the nucleus and controls the transcription of hedgehog target genes. c. The Wnt/β-catenin ...
Table 3. Estimated cancer deaths and mortality rates, overall, by sex and cancer type in China, 2016. ICD10SiteAllMaleFemale DeathsCrude mortality (1/105)ASMRW (1/105)DeathsCrude mortality (1/105)ASMRW (1/105)DeathsCrude mortality (1/105)ASMRW (1/105) C00-10,12-14 Lip, oral cavity...
Immune checkpoint expression and therapeutic implications in IDH1-mutant and wild-type glioblastomas Avaniyapuram Kannan Murugan, ... Ali S. Alzahrani April 2025 Read latest issue More from Current Problems in Cancer 21 July 2022 13 May 2020 ...
Researchers discovered that some cancers grouped together based on the cell type from which the tumor came from. For example, squamous cell cancers from the head and neck, lung, and bladder, cervix, and esophagus had strong molecular similarities and grouped together. ...
Cervical cancer (CC) is a leading cause of cancer-related death among women in developing countries. However, the underlying mechanisms and molecular targe