One exception is the DNABII family of proteins. These proteins exist in two subtypes, HU and IHF (histone-like protein from Escherichia coli strain U93 and integration host factor, respectively). HU is ubiquitous in Eubacteria. Although HU binds (weakly) and bends double-stranded DNA in a ...
Notably, EM analysis also revealed complex ‘branched’ replication structures, predominantly in BRCA2-depleted cells upon olaparib treatment (Supplementary Fig. 2B, C). Fig. 2: HR-independent induction of SCEs upon PARP inhibitor treatment. A RPE-1-TP53-/- cells with indicated dox-inducible ...
These, and reports of other keratin gene mutations, have highlighted the existence of mutation “hotspots” in keratin proteins at which sequence changes are most likely to be detrimental to protein function. Pathogenic mutations that occur outside these hotspots are usually associated with less ...
Nonetheless, the impact of different protein sources or crystalline AAs on ASCT2 function and expression is still in its infancy. For instance, while it has been suggested that D-Met is a better substrate than L-Met for ASCT2, D-serine appears to be transported by ASCT2 with lower ...
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Generally, PBDs are lower in fat (<1.5%) and protein (<1%), while the amount of carbohydrates is similar to that in milk (3–5%). The exceptions are oat drinks, which contain considerably more carbohydrates (~7%), and soy drinks, which contain a protein content similar to that of ...
So what’s going on when AI does something like predicting protein folding? One part of the story, I suspect, is that even though the physical process of protein folding has nothing to do with humans, the question of what aspects of it we consider significant does. We don’t expect that...
of the GFP protein. However to prevent leakage of siRNA outside the nanoparticles, the above were covalently grafted thereto. siRNAs were covalently bonded to a poly(ethylene oxide) chain intercalated in the nanoparticles and allowed the fixing of the siRNAs. In addition, a fluorescent marker (...
Basically, there are two possibilities for the expression of genes. In continuous expression, the gene is continuously expressed by means of a constitutive promoter and the corresponding protein accumulates in the cell. On the other hand, an inducible promoter is used in induced expression. The exp...
aIn primary rhinoplasty, supporting tissues can be conservatively reduced or rearranged to improve nasal contour. Normal existing supportive structures can be reshaped to change nasal contour. In secondary rhinoplasty, many patients must undergo construction of a new supporting structure that will provide...