60. Chong YH, Shin YJ, Lee EO, Kayed R, Glabe CG, Tenner AJ. ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures. J Biol Chem 2006; 281: 20315–20325. 61. D'Amelio M, Cavallucci V, ...
SeizuresAnticonvulsant effects of cannabidiol (CBD), a nonpsychoactive cannabinoid, have not been investigated in the juvenile brain. We hypothesized that CBD would attenuate epileptiform activity at an age when the brain first becomes vulnerable to neurotoxicity and social/cognitive impairments. To ...
The neurotoxicity induced by depolarization with high-K+ was investigated in rat hippocampal organotypic slice cultures. The exposure of cultures to 90 mM ... M Takahashi,SY Liou,M Kunihara - 《Brain Research》 被引量: 63发表: 1995年 Phosphorylation alters the pharmacology of Ca(2+)-activated...
neurotoxicity. Therefore, to expect PrP ablation to block toxicity in all aspects of all models would be to oversimplify a complex problem. The dependence of toxicity on particular receptors in individual animal models of AD may allow us to ascertain which models correctly mimic particular aspects ...
Dexmedetomidine reversed isoflurane-induced neuroapoptosis and in a dose dependent manner activation of alphaadrenoceptors. These studies demonstrate that anesthesia need not necessarily be associated with neurotoxicity in the young.1) Jevtovic-Todorovic V, J Neurosci 2003;23:876-82.2) Winzer-Serhan UH,...
Chemical neurotoxicity investigations using neural stem cells (NSCs) have shown that the use of these cells provides unique information for the identification of neurodevelopmental toxicants and their mechanism of action. Here, we review original articles on mechanistic data generated using NSCs derived ...
Furthermore, MCC950 treatment reversed the role of KHSRP from anti-inflammatory to pro-inflammatory. Keywords: neuroinflammation; KHSRP; manganese neurotoxicity; N2a cells; Parkinson's Int. J. Mol. Sci. 2022, 23, 13224. https://doi.org/10.3390/ijms232113224 https://www.mdpi.com/journal/ijms...
(2015) have found that rotenone attenuates ALDH2 activity in nerve cells in vitro, explaining some aspects of rotenone neurotoxicity. The present study results support their findings since a decrease in the ALDH2 activity in the ROT treated rats was noticed [55]. Cranberry juice did not ...