[1,4] Moreover a structural similarity between the [beta]-lactam ring and the inhibitory neurotransmitter [gamma]-aminobutyric acid (GABA) contributes to a decrease in normal GABA inhibition, allowing excitatory impulses to potentiate seizure-like activity. [1,5,6...
Hazard and risk assessment of nanomaterials (NMs) face challenges due to, among others, the numerous existing nanoforms, discordant data and conflicting results found in the literature, and specific challenges in the application of strategies such as grouping and read-across, emphasizing the need for...
ZIP4 is found to be upregulated in several types of cancer cells [53, 54, 58]. ZIP6 also plays an important role in numerous cancers, particularly breast cancer [47, 49, 56, 57, 71]. Overexpression of ZnT2 is found to decrease invasive phenotypes of breast cancer cells [72]. In ...
Naphthalene(Inhaled, this chemical,also found in mothballs, can contribute toautoimmuneissues,raise cortisol levels, and decrease thyroid function). Gel Foam Chemicals The same as above: memory foam chemicals Synthetic Latex Chemicals Styrene-butadiene copolymer(Non-toxic) ...
3 Mitigating long-term post–COVID-19 cognitive, emotional, and behavioral sequelae would decrease disease burden. COVID-19 neuropathology may serve as a model for deciphering neurodegenerative processes related to neuroinflammation in other brain diseases and developing new treatment strategies. Back to...
Activated microglia and subsequent release of PICs and glutamate, combined with reduced glutamate reuptake by activated astrocytes, can lead to the development of glutamate neurotoxicity with resulting damage to glutamatergic neurones and disruption to glutamatergic neurotransmission (Noda2016; Robel et al....
(1987) Free oxygen radicals decrease electrical resistance of microvascular endothelium in brain. Acta Physiol. Scand. 129, 181–187. [138] Haorah, J., Knipe, B., Leibhart, J., Ghorpade, A. and Persidsky, Y. (2005) Alcohol-induced oxidative stress in brain endothelial cells causes ...
The final section of the book explores air pollution and mental disorders, neurotoxicity, and the possible link between SARS-CoV-2 and the worsening of neurodegeneration. The underlying mechanisms and scale of air pollution effects remain largely unknown due to chemical and physical complexity. Individ...
Objectives To estimate the frequency of trigeminal nerve injuries associated with local anaesthetic administration, as experienced by UK dentists. Method A convenience sample of clinicians attending 12 study days over the UK was invited to complete an anonymised questionnaire exploring the nature of profes...
Some genetic variants can increase or decrease certain proteins that have been linked to a disease. If these variants can be identified – by computationally analysing enormous genetic datasets – then researchers can compare groups of people to see whether having the variant also increases the risk ...