Hand–foot skin reaction (HFSR), among the most significant adverse effects of sorafenib, has been limiting the clinical benefits of this frontline drug in treating various malignant tumors. The mechanism underlying such toxicity remains poorly understoo
Due to a lack of research on the critical non-coding RNAs in regulating ferroptosis, our study aimed to uncover the crucial ones involved in the process. We found that LINC01133 could make pancreatic cancer cells more resistant to ferroptosis. A higher e
The use of ruthenium gave higher stereoselectivities and better turnover numbers despite isomerization of the alkene to form an enol ether, which was not reduced under the reaction conditions (Scheme 7).23,24 Note that the chirality of the BINAP ligand is reversed between the two metals to ...
HIV-1 strains are differentiated into three neutralization tiers, determined by the relative ease of neutralization using plasma from untreated HIV-1-infected donors; tier-1 strains are highly susceptible to neutralization, while tier-2 and tier-3 strains present progressively increased resistance. HIV...
factorsor with anti-IFN-γ did not give rise to colony formation. Thus, activated NK cells can producehematopoietic growth factorsthat support BMC growth in vitro and their effect can be enhanced through the neutralization of inhibitory cytokines, such as IFN-γ, which are also produced. Protein...
et al. Enhanced neutralization of HIV by antibodies displayed on the S-layer of Caulobacter crescentus. Antimicrob. Agents Chemother. 55, 5547–5552 (2011). 9. Farr, C. et al. Development of an HIV-1 microbicide based on: blocking infection by high-density display of virus entry inhibitors...