因此,每个底物似乎都有自己的固定PKA池和自己的局部cAMP梯度。PKA通过抑制14-3-3蛋白与BAD(通过14-3-3/BAD signaling)和NFAT的相互作用,促进细胞存活。PKA通过限制其在红血球中谱蛋白-肌动蛋白网络组装过程中的作用来,抑制内收蛋白的作用,从而降低了红血球白血病的几率。激活KDELR(KDEL内质网蛋白保留受体),促进高尔...
因此,每个底物似乎都有自己的固定PKA池和自己的局部cAMP梯度。PKA通过抑制14-3-3蛋白与BAD(通过14-3-3/BAD signaling)和NFAT的相互作用,促进细胞存活。PKA通过限制其在红血球中谱蛋白-肌动蛋白网络组装过程中的作用来,抑制内收蛋白的作用,从而降低了红血球白血病的几率。...
因此,每个底物似乎都有自己的固定PKA池和自己的局部cAMP梯度。PKA通过抑制14-3-3蛋白与BAD(通过14-3-3/BAD Signaling)和NFAT的相互作用,促进细胞存活。PKA通过限制其在红血球中谱蛋白-肌动蛋白网络组装过程中的作用来,抑制内收蛋白的作用,从而降低了红血球白血病的几率。激活KDELR (KDEL内质网蛋白保留受体),促进高...
cAMP-elevating agents, such as forskolin, can not only induce cancer cell death, but also directly inhibit cell proliferation in some cancer types. In this review, we summarize current understanding of cAMP signaling in cancer biology and immunology and discuss the basis for its context...
ObjectiveTo investigate the possible role of tag single nucleotide polymorphisms in cAMP signaling pathway in patients with recurrent major depressive disorder in Chinese Han population. Methods1 030 patients with recurrent major depressive disorder according to the DSM-Ⅳ criteria were recruited as case ...
关键词骨癌痛;感觉神经元;脊髓;环磷酸腺苷;蛋白激酶AACTIVATIoNoFcAMP-PKASIGNALINGPATHWAYCONTRIBUTESTOINDUCTIONANDMAINTENANCEoFBoNECANCERPAIN$HEDuan—Duan,GUOXiang.Yang△(DepartmentofAnesthesiology,TheThirdAfiliatedHospital,PekingUniversity,Beijing100191)Abstract0bjective:ToexploretheroleofcAMP—PKAsignalingpathwayin...
Actin induction during PMA and cAMP ⁃ dependent signal pathway activation in Entamoeba histolytica trophozoites[J]. Cell Microbiol, 2000, 2(5): 391⁃400. [3] Farrow B, Rychahou P, Murillo C, et al. Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel ...
LINC01585NONOTumor growthObjective: Breast cancer is the leading cause of cancer death among women. Nowadays, long non-coding RNAs (lncRNAs) have been identified and emerged as critical bio-markers in breast cancer tumorigenesis and progression. However, only a handful of lncRNAs which are ...
Cheng, Y., Gao, XH., Li, XJ.et al.Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway.Oncogene37, 2953–2966 (2018). https://doi.org/10.1038/s41388-018-0177-4 Download citation
Androgens transduce the G-alpha s-mediated activation of protein kinase A in prostate cells: Y. Daaka, et al. ; Cancer Res. 68, 3225 (2008), Application(s): EIA using human cell lysates,Abstract; beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured ...