As such, some bias in the ascertainment of the full spectrum of mutations could have occurred. The retrospective likelihood approach allows correcting for this bias.17 For cohort 1, carriers of BRCA2 mutations composed a smaller sample set; in particular, the number of women with BRCA2-...
Full-length human ATXN3 cDNA was previously cloned from total mRNA isolated from SCA3 patient-derived fibroblasts (GM06153, obtained from NIGMS Human Genetic Cell Repository at the Coriell Institute for Medical Research).99 The cloning strategy used for the constructs expressing translated or untransla...
CAG repeats RNA causes various fatal neurodegenerative diseases exemplified by Huntington’s disease (HD) and several spinocerebellar ataxias (SCAs). Although there are differences in the pathogenic mechanisms, these diseases share the common cause, i.e.
Correia SS, Bassani S, Brown TC, Lisé MF, Backos DS, El-Husseini A, Passafaro M, Esteban JA (2008) Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation. (Translated from eng). Nat Neurosci 11 (4):457–466 (in eng) 22. Takahashi S, Kubo K,...
Full size table Figure 4 Reaction time and performance of female R6/2_50 mice during cognitive testing in the touchscreen. Data show the mean reaction times (as the time taken to respond to the first presentation of a stimulus pair) during acquisition and reversal during testing Phase 2 (A...