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Conclusions: Based on our data, we speculate that the CAG repeat polymorphism is associated with coronary heart disease in the Chinese population and the (CAG)(9) allele may be an independent predictive factor for CAD.doi:10.1515/CCLM.2007.159Han, Yaling...
pylori strain 26695, its modified form Hp/cagW-FL and its isogenic mutants were grown on BHI (Brain-heart Infusion) agar plates under micro-aerophilic condition as described previously [24]. List of bacterial strains and plasmids used in the study are given in Tables S1 and S2, respectively...
Here we optimised a differentiation system of ES cells into Flk1+ mesodermal cells, ECs and SMCs and subsequently used the cells to form angiogenic sprouts in vitro. We then evaluated a number of plasmid vector systems for expressing transgenes during differentiation to Flk1+mesodermal cells and ...
In order to assess the role of repeat context, we have inserted a 146-unit CAG repeat into exon 3 of the murine Hprt gene. The resulting mutant allele (hprt(CAG)146) codes for a full-length HPRT protein with an insertion of a long polyglutamine stretch near its N terminus. Mice with ...
Full-TextCite this paperAdd to My Lib Abstract: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in the HTT gene encoding huntingtin. The disease has an insidious course, typically progressing over 10-15 years unti...
Here we optimised a differentiation system of ES cells into Flk1+ mesodermal cells, ECs and SMCs and subsequently used the cells to form angiogenic sprouts in vitro. We then evaluated a number of plasmid vector systems for expressing transgenes during differentiation to Flk1+mesodermal cells and ...