In DM1 both progenitor CTG•CAG repeat length and somatic expansion determine age of onset and severity of disease, which is characterized by muscular dystrophy and myotonia in combination with a highly variable manifestation of features like cataract, heart conduction defects, insulin insensitivity ...
Here we optimised a differentiation system of ES cells into Flk1+ mesodermal cells, ECs and SMCs and subsequently used the cells to form angiogenic sprouts in vitro. We then evaluated a number of plasmid vector systems for expressing transgenes during differentiation to Flk1+mesodermal cells and ...
Long polyglutamine repeats were shown to be less toxic in vivo when expressed in a full-length SCA3 protein than when expressed in a truncated version of the protein (Ikeda et al. 1996). Furthermore, the in vitro formation of aggregates similar to NIIs has been shown to be enhanced by ...
Conclusions: Based on our data, we speculate that the CAG repeat polymorphism is associated with coronary heart disease in the Chinese population and the (CAG)(9) allele may be an independent predictive factor for CAD.doi:10.1515/CCLM.2007.159Han, Yaling...
The scholarship provided in Enriched Classics enables readers to appreciate, understand, and enjoy the world's finest books to their full potential. The Dialogues of Plato; Volume 2 Plato This work has been selected by scholars as being culturally important and is part of the knowledge base of ...
Full-TextCite this paperAdd to My Lib Abstract: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in the HTT gene encoding huntingtin. The disease has an insidious course, typically progressing over 10-15 years unti...
Every page literally pops out with creative 3-D engineering in full color, while pull-tabs allow readers to bring a Quidditch game to life or help Harry see his heart's desire in the Mirror of Erised. The cartoonish art is muddy and unspectacular, but fans and collectors blinded by their...
eventually transforming into Shenyang No.6 Machine Factory. In 1953, the factory underwent a name change, becoming known as Shenyang Pump Factory. In 1959, the factory site was moved to No. 28 Xiongjiagang Road, Tiexi District, Shenyang. At that time, this factory was full of devastation an...