Our in vivo HttQ111 CRISPR–Cas9 editing platform thus provides a highly efficient means of screening and identifying novel expansion-modifying genes and their interactions, although it is worth noting that the absence of an effect in this system does not necessarily preclude a role for a particula...
Each of the stages of testing was analysed in terms of performance (percentage correct), reaction time (time taken for the mouse to respond to the initial presentation of the stimulus), number of correction trials required to complete a session, and mean number of sessions required to reach cr...
RNA molecules with the expanded CAG repeat (eCAGr) may undergo sol–gel phase transitions, but the functional impact of RNA gelation is completely unknown. Here, we demonstrate that the eCAGr RNA may form cytoplasmic gel-like foci that are rapidly degrad
In order to account for multiple testing, we applied a false discovery rate correction as described by Benjamini and Hochberg, assuming eight independent tests with a two-sided α of 0.05.39 All data are displayed as means and 95% confidence intervals (CIs), unless otherwise specified. All ...
group medical and dental plans for the Executive, his spouse and his dependents, as applicable, on the same terms as such plans are being provided to all of the Company's United States senior executives during the Continuation Period (or such longer period as is provided in such plans) and...