为了研究ESCRT-III在ferroptosis中的功能作用,作者评估了抑制CHMP4B对NIH-3T3细胞死亡的影响(图5A, B)。与对照组相比,CHMP4B敲除细胞的死亡发生率更高、更快,特别是在早期时间点(1-3 h),这表明CHMP4B的缺失导致细胞对ferroptosis的敏感性更高...
铁死亡(Ferroptosis)是一种不依赖caspase的调控细胞坏死形式,其特征是在细胞膜上产生铁依赖的脂质过氧化物。Ferroptosis发生的一个基本步骤是破坏质膜。然而,导致Ferroptosis质膜完整性丧失的分子机制以及膜损伤的性质和大小尚未得到深入研究。其他形式的细胞死亡如坏死、焦亡或毒素诱导的细胞死亡会导致离子通量的激活。在这些...
tamoxifen increases the expression of TRPC1, a calcium channel located on the plasma membrane, and thereby causes the cytoplasmic accumulation of excessive amounts of Ca2+, which ultimately leads to the generation of reactive oxygen species (ROS), lipid peroxidation and cell death by ferroptosis. ...
Ferroptosis is an iron-dependent form of regulated necrosis associated with lipid peroxidation. Despite its key role in the inflammatory outcome of ferroptosis, little is known about the molecular events leading to the disruption of the plasma membrane during this type of cell death. Here we show ...
The presence of Wnt5a/Ca2+ signaling ligand Wnt5a protein increased the silica-induced macrophage ferroptosis by activating ER-mediated immunoglobulin heavy chain binding protein (Bip)-C/EBP homology protein (Chop) signaling cascade, reducing the expression of negative regulators of ferroptosis, ...
铁死亡(Ferroptosis)是一种依赖铁和脂质过氧化的细胞死亡形式,但其在脂肪组织中的作用尚不明确。浙江大学王福俤教授团队研究发现,肥胖患者及高脂饮食小鼠的脂肪组织中铁死亡信号显著下调。进一步研究表明,非致死剂量的铁死亡激动剂可减少脂肪细胞脂质积累,并...
铁死亡(Ferroptosis)是2012年由Dr. Brent R Stockwell团队提出的一种铁依赖性的脂质过氧化驱动的细胞死亡形式,不同于凋亡和其他形式的细胞死亡。铁死亡与包括发育、衰老、免疫与癌症在内的诸多生物过程密切相关。目前铁死亡在肿瘤生物学和癌症治疗中的研究也已经...
In summary, our study reveals a previously unrecognized role of PIEZO1 in modulating ferroptosis, providing a new target for future mitigation of radiation-induced lung injury. 展开 关键词: Piezo1 VE-cadherin calpain ferroptosis ionizing radiation ...
Notably, necrostatin-1, an inhibitor of necroptosis-inducing, receptor-interacting Ser/threonine-protein kinase 1,52 provided partial but significant protection, while ferrostatin-1, which inhibits ferroptosis by trapping peroxyl radicals,53 had no protective effect (Figure 7I). Finally, we examined ...
SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans Inge E. Krabbendam Birgit Honrath Amalia M. Dolga Cell Death & Disease (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface Lucie Coppi...