我们的研究表明,与步态和凝视控制相关的功能网络在疾病过程中同时发生改变。 https://doi.org/10.1093/brain/awaa407 3,阿尔兹海默症海马CA1区的突触组织的三维分析 期刊:Brain 作者:CholeFu 含有CA1区的人类海马的显微照片 阿尔茨海默...
参考文献: [1] O'Keefe, J. & Dostrovsky, J. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain. Res. 34, 171–175 (1971). [2] Fyhn, M., Molden, S., Wit...
Transient ischemia induces anearly decrease of synaptic transmission in CA1 neurons of rat hippocampus: electrophysiologic study in brain slice J. J 12、Cereb Blood Flow Metab, 1997, 17(9): 955966.4 Ikeda J, Terakawa S, Muyota S, et al. Nuclear disintegration as a leading step of ...
Tab畅1 Thenumberofsurvivalneuronsinunitbrainareaof CA1regionofhippocampus(n=15,x±s) Group No.ofsurvivalneurons (t/d)7 1430┅ SH43±5j47±344±2骀 NS49±546±343±4骀 eGFP47±445±447±5骀 3 讨 论 基因治疗的关键和基础是基因转移 ,目的基因 导入靶细胞并使之表达是其关键环节。 2005 年...
Supplementary Figure 2 Other input mapped brain regions for different SUB neuron types. a, Input connection mapping of CA1-projecting SUB excitatory neurons. Input mapped neurons in the medial septum and diagonal band (MS/HDB), anterior ventral thalamus (AV Thalamus), auditory cortex (Aud Ctx),...
This process occurs throughout life in the hippocampus of the mammalian brain. The process of neurogenesis is a striking example of the high capacity for neural plasticity that exists throughout the lifespan in the central nervous system. This......
期刊:Brain 作者:CholeFu 含有CA1区的人类海马的显微照片 阿尔茨海默病(AD)是痴呆症中最常见的一种,其特征是认知功能的持续和进行性损害。AD通常与淀粉样β肽的细胞外沉积和神经元内异常磷酸化的tau蛋白积累有关,即淀粉样β和神经纤维病变。这些病理导致神经元变性和突触改变被认为是构成AD认知功能障碍的主要神经...
brain,weemployedlarge-scale in vivoensemble recordingtechniques tomonitorthe activitypatterns of simultaneously recorded hippocampal CAl pyramidal cellsandvariousintemeurons during several consciousandunconsciousstatessuchasawake rest,runningslow wave sleep, and ketamine—inducedanesthesia.Our analyses revealthatketa...
The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral hippocampal CA1 (vCA1) neurons of a mouse and their projections to nucleus...
However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral hippocampal CA1 (... T Okuyama,T Kitamura,DS Roy,... - 《Science》 被引量: 52发表: 2016年 Ventral CA1 neurons store social memory The medial temporal lobe,...