More recently, however, C282Y has been reframed as a potential risk in the context of contemporary, iron fortified diets.doi:10.1002/ajpa.24520Burke, StacieDuffy, ThomasAmerican Journal of Biological Anthropology
Results: Results showed a significant difference between case and controls regarding C282Y (P value < 0.001) and H63D genotypes (P value = 0.013). We also found a relationship between both mutations and nephropathy. Moreover, the difference between C282Y genotypes of patients with retinopathy ...
遗传性血色素沉着症HFE C282Y基因
Distribution of the C282Y and H63D polymor- phisms in hereditary hemochromatosis patients from the French Basque Country. Ann Hematol 2005; 84: 99- 100.Bauduer F, Scribans C, Degioanni A, Renoux M, Dutour O. Distribu- tion of the C282Y and H63D polymorphisms in hereditary hemochro-...
We sought to compare frequencies of HFE C282Y and H63D alleles and associated odds ratios (OR) in 100 consecutive unrelated white adults with malignancy to those in 318 controls. Data from patients with more than one malignancy were analyzed according to
43 concluded that the penetrance of clinical disease in HH was unknown, one can estimate the clinical penetrance of a genotype, such as HFE C282Y homozygosity, as the cumulative incidence of disease to age 70 using a life-table model and age-specific prevalence estimates.46 The purpose of ...
JAMA:HFE p.C282Y纯合子年长人群的肝癌风险显著增加 HFE p.C282Y纯合子是造成遗传病滴血色素沉着症候群主要致病生物体。病理病症候群为遗传病滴血色素沉着症候群的患者中的,肝病及生还效用增加,但对于大多数不曾确诊的p.C282Y纯合子病毒感染,高血压肝病效用尚不相符。近日研究工作其他部门深入研究工作了HFE...
To study C282Y mutation in the HLA-H gene of 173 survivors of myocardial infarction matched with 172 controls by age, race, and sex, and 119 patients upon diagnosis of acute myocardial infarction. Identification of the mutation was performed by PCR amplification of the DNA fragment followed by...
The carriage of H63D risk allele (OR = 1.54; P = 0.02), heterozygous C282Y/wt and homozygous H63D/H63D genotypes were associated with liver cirrhosis in males (OR = 2.48, P = 0.008, and OR = 4.13, P = 0.005, respectively). Conclusions Heterozygous C282Y mutation of the HFE gene ...
We retrospectively studied non-Hispanic white hemochromatosis probands with iron overload (serum ferritin (SF) > 300 µg/L (M), > 200 µg/L (F)) and p.C282Y/p.C282Y at non-screening diagnosis who did not report alcohol consumption > 14 g/d, have cirrhosis or other ...