(2010) Association between C282Y and H63D mutations of the HFE gene with 3 4 2 hepatocellular carcinoma in European populations: a meta-analysis. J. Exp. Clin. Cancer Res., 5 6 3 29, 18. 7 8 9Jin F, Qu LS, Shen XZ (2010) Association between C282Y and H63D mutations of the ...
The C282Y and H63D mutations in the HFE gene are important causes of hemochromatosis. In the elderly, these mutations might be associated with increased morbidity because of the lifelong accumulation of iron. In a population-based sample of the elderly, we determined the value of genotyping for...
The distribution of HFE mutations was studied in patients from the French Basque Country with hereditary hemochromatosis (HH). The C282Y mutation was underrepresented but H63D seemed to demonstrate the highest prevalence when compared with other European countries. In addition, symptomatic HH was rarer...
The gene responsible for hereditary hemochromatosis close to the human leukocyte antigen A locus was previously identified and designated as HFE. This study was performed to evaluate the clinical significance of two mutations, C282Y and H63D of HFE, in Japanese patients with hepatic iron overload....
The aim of this study was to determine the association between heterozygous C282Y and H63D mutations and non-HH liver cirrhosis in Lithuanian population. Materials and methods The patient cohort consisted of 209 individuals. Diagnosis of cirrhosis was confirmed by clinical, laboratory parameters, ...
Each of ten patients had two detectableHFEmutations (HFEgenotypes C282Y/C282Y, C282Y/H63D, or H63D/H63D). A man with Burkitt lymphoma and a woman with adenocarcinoma of the tail of the pancreas had the genotype C282Y/C282Y; both had elevated serum transferrin saturation values and iron ...
Objective:The gene responsible for hereditary hemochromatosis close to the human leukocyte antigen A locus was previously identified and designated as HFE. This study was performed to evaluate the clinical significance of two mutations, C282Y and H63D of HFE, in Japanese patients with hepatic iron ...
Ferritin concentrations in synovial fluid are higher in osteoarthritis patients with HFE gene mutations (C282Y or H63D). Scand J Rheumatol 2010; 39(5):413-20.Carroll GJ, Sharma G, Upadhyay A, Jazayeri JA. Ferritin concentrations in synovial fluid are higher in osteoarthritis patients with HFE ...
Significance of HFE gene mutations in chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis: Andreas Erhardt, Heinrich-Heine-University Duesseldorf, Duesseldorf Germany; Andrea Maschner-Olberg, Heinrich-Heine University, Duesseldorf Germany; ...
protocol, where the initial step is a time consuming and oftenexpensive DNA extraction. The Sample-to-SNP kit was validated using the HFE p.H63D and p.C282Y single base DNA variations and eight other SNPs that were used as well to give the comparison more power. The eight ...