C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this ...
To shed light on this area, we employed solution state Nuclear Magnetic Resonance spectroscopy to probe the dynamics of the C2A domain of dysferlin as a function of calcium and PI(4.5)P2 binding. We found that calcium binding attenuates millisecond to microsecond protein motions both in the ...
luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids). 仅用于科研。不用于诊断过程。未经明确授权不得转售。 相关产品 免疫组织化学 Secondary Antibodies 同型对照 IHC封片剂 IHC细胞计数染料...
Synaptotagmin-1 membrane binding is driven by the C2B domain and assisted cooperatively by the C2A domainExocytosisMolecular conformationSynaptotagmin interaction with anionic lipid (phosphatidylserine/phosphatidylinositol) containing membranes, both in the absence and presence of calcium ions (Ca), is ...
磷酸化易感候选基因3抗体人S100钙结合蛋白A8/A9复合物(S100A8/A9)ELISA KitHuman S100 calcium-binding protein A8/A9 complex,S100A8/A9 Elisa kit 磷酸化CREB-1抗体人S100钙结合蛋白A6/钙粒蛋白A(S100A6)ELISA KitHuman S100A6 ELISA Kit 磷酸化CREB-1抗体人S100钙结合蛋白A12/钙粒蛋白C(S100A12)ELISA Kit...
Protein kinases like LRR receptor-Like protein kinase, serine/threonine-protein kinase and calcium-dependent protein kinase function in most biological processes of plant life [101,102,103]. Although we observed regulation of these genes by ZmMYC2 here, the regulatory function and mechanism should ...
www.nature.com/scientificreports OPEN C2-domain mediated nano-cluster formation increases calcium signaling efficiency received: 19 February 2016 accepted: 18 August 2016 Published: 03 November 2016 Mike Bonny1,*, Xin Hui2,*, Julia Schweizer2, Lars Kaestner2, André Zeug3, Karsten ...
RA. We also explored the roles of the target C2 domain-containing protein using RA FLSs and several experimental mouse models. Finally, to clarify the mechanisms by which the candidate protein and its C2 domain act against RA, we evaluated its binding with calcium and protein‒protein ...
2016. Dynamic response of the C2 domain of protein kinase Calpha to Ca(2þ) binding. Biophys J. 111:1655-1667. Yang,Yuan,Igumenova,... - 《Biophysical Journal》 被引量: 0发表: 2016年 Role of intracellular calcium mobilization in the regulation of protein kinase C-mediated membrane proc...
Caloxin 1c2 had been selected for binding to the extracellular domain 1 (amino acids 115–131) of PMCA isoform 4. Caloxin 1c2 and the extracellular domain 1 peptide of PMCA 4 competed with 3Bpa-caloxin 1c2 for photolabeling the erythrocyte membranes. Pieces of de-endothelialized pig ...