Preusser等利用荧光原位杂交法和免疫组织化学法检测了209例NSCLC患者脑转移病灶,发现21.6%存在c-Met基因扩增,44.4%存在c-Met蛋白过表达,并观察到c-Met蛋白表达与c-Met基因状态呈显著正相关,且经过分析发现,c-Met蛋白过表达则主要通过c-Met基因扩增诱导产生。 其实,大多数非小细胞肺癌中均可见c-Met蛋白的过表达, ...
1. Shawna Leslie Organ and Ming-Sound Tsao, An overview of the c-MET signaling pathway. Therapeutic Advances in Medical Oncology.2. Yazhuo Zhang, et al. Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities. Molecular Cancer.3. Carmen, et al....
1980s中期,mesenchymal epithelial transition factor receptor (MET, c-Met)首次被发现,1990s发现c-Met突变与肺癌的关联,并在后续逐步阐明c-Met基因重排、扩增、突变以及上调表达与肺癌患者临床获益关联。 c-Met靶点生理功能与调节:c-Met在组织正常发育和肿瘤进展中发挥关键作用 c-Met位于染色体7q21–q31,21个外显...
c-METHGF治疗检测Hepatocyte growth factor/c-MET (HGF/c-MET) signaling pathway can be abnormal activated by many mechanisms such asc-MET mutation, ampliifcation and the overexpression of HGF, and it plays an important role in the development of non-small cell lung cancer (NSCLC), as well as...
一般来说,只有存在MET基因改变的患者在接受抗c-MET药物后才会有客观反应;而对于存在野生型MET的患者而言,靶向HGF/MET信号通路通常对癌细胞生长影响不大。 据近期报道,抑制c-MET的药物对有高水平MET扩增或METex14跳跃突变的患者相当有...
An overview of the c-MET signaling pathway 二.HGF/c- MET信号通路异常的3种常见形式 c-MET重排(rearrangement)、激活突变(mutation)和基因扩增(amplification); c-MET蛋白的上调表达(overexpression); 配体依赖的c-MET蛋白持续激活...
肺癌met细胞hgf机制nsclc ·745·中国肺癌杂志2015年12月第18卷第12期ChinJLungCancer,December2015,Vol.18,No.12·综述·c-MET在非小细胞肺癌中的作用机制及其治疗和检测梁红格王孟昭【摘要】肝细胞生长因子/c-ME (hepatocytegrowth actor/c-ME ,HGF/c-ME )信号通路可通过多种机制如c-MET突变、扩增、过表达和...
[Key words] HGF/c-Met signaling pathway;Colorectal carcinoma;Liver metastasis;Inhibitor 结直肠癌是世界范围内最常见的恶性肿瘤之一,近年来我国结直肠癌发病率和患病率呈明显上升趋势。结直肠癌发生局部淋巴结转移最为常见,其次是出现远处器官转移,其中肝脏是最常见的远处转移靶器官。初诊结直肠癌患者中发现淋巴结转...
The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal cell development and motility. Aberrant activation of c-MET can lead to both tumors growth and metastatic progression of cancer cells. C-MET can be activated by e
Met signaling pathway inhibitors is also reviewed.%c-Met和肝细胞生长因子(HGF)在很多肿瘤细胞组织中高表达.c-Met信号通路的活化引起一系列的信号级联放大反应,导致了肿瘤细胞的生长、增殖、侵袭和凋亡减少.HGF是c-Met的配体,参与并影响肿瘤微环境的形成.该文就HGF如何活化c-Met及其下游的信号通路、c-Met与其他...