[3] Anestis A, Zoi I, Karamouzis M V. Current advances of targeting HGF/c-MET pathway in gastric cancer[J]. Annals of translational medicine, 2018, 6(12). 举报/反馈 发表评论 发表 作者最新文章 先导论坛|RNAi药物开发历史、原理和应用前景 7天前2阅读 病毒感染是否对孕妇肠道菌群产生影响并波及...
位于7号染色体的7q31区域.MET转录形成6641bp的mRNA,译形成含有1390个氨基酸的蛋白质.2、该基因蛋白结构、关键功能域、参与的pathway及发挥的功能TyrlflTyri3rtMET是一种由单链受体酪氨酸激酶MET蛋白由细胞外高度糖基化的I亚基和跨膜的3亚基构成,两个亚基由两个二硫键相连4.细胞外结构:信号蛋白的同源区包裹整个...
[2] Comoglio P M, Trusolino L, Boccaccio C. Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy[J]. Nature Reviews Cancer, 2018, 18(6): 341-358. [3] Anestis A, Zoi I, Karamouzis M V. Curre...
1. De Silva DM, et al. Targeting the hepatocyte growth factor/Met pathway in cancer. Biochem Soc Trans. 2017;45(4):855-70. 3. Spigel DR, et al. Results From the Phase III Randomized Trial of Onartuzumab Plus Erlotinib Versus Erlotinib in Previously Treated Stage IIIB or IV Non-Small-C...
[3] Anestis A, Zoi I, Karamouzis M V. Current advances of targeting HGF/c-MET pathway in gastric cancer[J]. Annals of translational medicine, 2018, 6(12).
1. De Silva DM, et al. Targeting the hepatocyte growth factor/Met pathway in cancer. Biochem Soc Trans. 2017;45(4):855-70. 3. Spigel DR, et al. Results From the Phase III Randomized Trial of Onartuzumab Plus Erlotinib Versus Erlotinib in Previously Treated Stage IIIB or IV Non-Small-...
Development of c-MET pathway inhibitors. Expert Opin Investig Drugs 2011;20:1225-41.Liu X,Newton R C,Scherle P A.Development of c-METpathway inhibitors. Expert Opinion on Investigational Drugs . 2011Liu X, Newton RC, Scherle PA (2011) Development of c-MET pathway inhibitors. Expert Opin ...
Papa E, Weller M, Weiss T, Ventura E, Burghardt I, Szabo E. Negative control of the HGF/c-MET pathway by TGF-β: a new look at the regulation of stemness in glioblastoma. Cell Death Dis. 2017;8:3210. doi:10.1038/s41419-017-0051-2....
一般来说,只有存在MET基因改变的患者在接受抗c-MET药物后才会有客观反应;而对于存在野生型MET的患者而言,靶向HGF/MET信号通路通常对癌细胞生长影响不大。 据近期报道,抑制c-MET的药物对有高水平MET扩增或METex14跳跃突变的患者相当有...
development and prognosis oflung cancer. Because the role of c - Met signaling pathway in the progress and invasion of lung cancer has been widelystudied,c - Met related inhibitors show antitumor activity in both preclinical and clinical trials of lung cancer. There-fore,this paper briefly ...