c-Jun NH2-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family that regulate multiple aspects of liver cell biology in the healthy and diseased liver. JNKs exert key functions in the control of proliferation, cell death, survival, and inflammation. ...
c-JunNH-terminalkinase(JNK)-interactingprotein-3(JIP3)highlyexpressedaxontipsduringcriticalperiodaxondevelopment.Usinggain-loss-of-functionapproaches,immunofluorescenceanalysisuteroelectroporation,wefindJIP3canenhanceaxonelongationprimaryhippocampalneuronscorticalneuronsvivo.WefurtherdemonstrateJIP3promotesaxonelongationJNK-...
Both corresponded to the c-Jun NH2-terminal kinase (JNK) 3. In the present study, genomic cloning re- vealed that the JNK3 gene consists of 14 exons interrupted by 13 introns; its transcription-initiation site is within exon 3 and the termination codon lies in exon 14. Fluorescence in ...
In this study we show that the structurally unrelated antioxidant agents pyrrolidine dithiocarbamate (PDTC), butylated hydroxyanisole, and Nacetylcysteine activated JNK (c-Jun NH2-terminal kinase) in Jurkat T cells. This activation differed substantially from that mediated by phorbol 12-myristate 13-...
Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines. Oncogene 22: 8797-8801.Hideshima T, Hayashi T, Chauhan D, et al. Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines. Oncogene 2003;22:8797-...
The c-Jun NH(2)-terminal kinase (JNK) signaling pathway is induced by cytokines and stress stimuli and is implicated in cell death and differentiation, but the specific function of this pathway depends on the cell type. Here we examined the role of JNK1 and JNK2 in CD8(+) T cells. Un...
PURPOSE: C-Jun NH(2)-terminal kinase (JNK) has been implicated in numerous functions including stress responses, apoptosis,and transformation. The role in transformation is based largely on studies of isolated cell types with little indication of whether JNK plays a general role in a specific hum...
Jun N-terminal kinase (JNK) regulates the transcription factor AP-1, which is implicated in the controlled expression of many genes involved in the immune response. For this reason, drug discovery efforts have focused on the development of JNK inhibitors for chronic inflammatory diseases. However,...
c-Jun_N-terminal_kinase抑制剂_激动剂_MCE JNK c-Jun N-terminal kinase protein kinase family, and are responsive to stress stimuli, such as cytokines,ultraviolet irradiation, heat shock, and osmotic shock. JNKs play a role in T cell differentiation and the cellular apoptosis pathway.Activation ...
the functional role of c-Jun NH2 -terminal kinase (JNK) during infection-induced thymic atrophy was addressed. The levels of phosphorylated JNK in immature CD4(+) CD8(+) thymocytes from C57BL/6 (Nramp-deficient) and 129/SvJ (Nramp-sufficient) mice were increased upon oral infection of...