c Jun N terminal kinase 2; c Jun N terminal kinase 3; c-Jun N-terminal kinase 1; JNK 46; JNK 55; JNK; MAP kinase 10; MAP kinase 9; MAP kinase 8;Mitogen activated protein kinase 10; Mitogen activated protein kinase 9; Mitogen activated protein kinase 8; PRKM9; PRKM8; PRKM10 ...
Since serine 34 is a major site of phosphorylation of mouse p53 in vivo and its specific protein kinase is still not definitively identified yet, we have examined the c-Jun N-terminal kinase 1 (JNK1) activity on p53 by expressing JNK1 in 293T cells. We show here that activated JNK1 ...
【产品介绍】C-Jun N-terminal kinases (JNK) are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group consists of three isoforms (JNK1, 2, and 3) and regulates transcription activity of the...
c-jun氨基末端激酶[c-junn-terminalkinases(jnk)]最早被定义为压力活化蛋白激酶[stress-activatedproteinkinases(sapk)],是一种丝苏氨酸激酶,属于丝裂原活化蛋白激酶[mitogen-activatedproteinkinase(mapk)]家族成员。哺乳动物的jnks由三种不同的基因编码,分别为jnk1、jnk2、jnk3,经选择性剪接有十余种蛋白产物,分子量...
蛋白别名: c-Jun kinase 2; c-Jun N-terminal kinase 2; JNK; JNK-55; JNK1; JNK1A2; JNK21B1/2; Jun kinase; MAP kinase 9; MAPK 10; MAPK 9; MAPK10; MAPK8; Mitogen-activated protein kinase 9; OTTHUMP00000161542; OTTHUMP00000161543; PRKM8; SAPK1; SAPK1a; Stress-activated protein kina...
The c-Jun NH(2)-terminal kinase (JNK) signaling cascade has been implicated as a mediator of MPTP-induced apoptotic neuronal death based on the ability of CEP-1347/KT-7515, an inhibitor of JNK activation, to attenuate MPTP-induced nigrostriatal dopaminergic degeneration. In these studies, MPTP...
C-Jun N-terminal Kinase (JNK) is also known as Mitogen-activated protein kinase (MAPK8). It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal ...
中文名: JNK-IN-8是JNK1,2和3抑制剂,IC50分别为4.67,18.7和0.98 NM,能抑制C-JUN的磷酸化。 中文别名: JNK-IN-8是JNK1,2和3抑制剂,IC50分别为4.67,18.7和0.98 NM,能抑制C-JUN的磷酸化。 CBNumber: CB75772507 分子式: 分子量: 0 MOL File: Mol file 化学...
Non-visual arrestins scaffold mitogen-activated protein kinase (MAPK) cascades, bringing together three components of MAPK signaling modules. The c-Jun N-terminal kinases (JNKs) are members of MAPK family and three JNKs isoforms (JNK1, JNK2, and JNK3) have been identified. JNK1 and JNK2 ...
c-Jun N-terminal kinase (JNK)-dependent alternative processing of Bid to jBid was also reported. We have previously shown that the folate stress enzyme 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) activates JNK1 and JNK2 in cancer cells as a pro-apoptotic response. Here we report that ...