c-Jun N-terminal kinase pathway activation in human and experimental cerebral con- tusion. J Neuropathol Exp Neurol 2009; 68: 964-971.Ortolano F, Colombo A, Zanier ER, Sclip A, Longhi L, Perego C, et al. c-Jun N-terminal kinase pathway activation in human and experimental cerebral ...
Hao Z, Xing Z, Tan J, Zhao Y, Li M. Impinging Flow Induces Expression of Monocyte Chemoattractant Protein-1 in Endothelial Cells Through Activation of the c-Jun N-terminal Kinase/c-Jun/p38/c-Fos Pathway [publi...
c- jun N-terminal kinaseParkinson's disease (PD) is a severe and progressive neurodegenerative disease. It is the second most common neurodegenerative ... N Lev,E Melamed,D Offen - 《Progress in Neuropsychopharmacology & Biological Psychiatry》 被引量: 386发表: 2003年 GSK3 inhibitors show bene...
c-Jun N-terminal kinase or stress activated protein kinase is activated by various stress stimuli, including DNA damage. Both cis and trans forms of cisplatin activate the JNK pathway. p73, a proapoptotic member of p53 forms a complex with JNK leads to cisplatin induced apoptosis (Jones et al...
Inhibiting c-Jun N-terminal kinase (JNK)-mediated apoptotic signalingpathway in PC12 cells by a polysaccharide (CCP) from Coptis chinensisagainst Amyloid-β (Aβ)-induced neurotoxicityYujuan Lia , Bingmei Wang a , Cong Liu a , Xiaoting Zhu a , Pengqi Zhang a , Hongkui Yu a , Yunqiang...
Galectin-1 (gal-1), an endogenous-galactoside-binding protein, triggers T-cell death through several mechanisms including the death receptor and the mitochondrial apoptotic pathway. In this study we first show that gal-1 initiates the activation of c-Jun N-terminal kinase (JNK), mitogen-...
Systemic injections of kainic acid (KA) cause epileptic seizures with delayed neuronal damage in the limbic system, particularly in the hippocampus. KA excitotoxicity activates complex signal transduction events that trigger apoptotic cell death. The ...
c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling C. A. Escudero, C. Cabeza, G. Moya-Alvarado, M. T. Maloney, C. M. Flores, C. Wu, F. A. Court, ...
Background: Inhibition of the c-Jun N-terminal kinase (JNK) pathway by the TAT-coupled peptide XG-102 (formerly D- JNKI1) induces strong neuroprotection in ischemic stroke in rodents. We investigated the effect of JNK inhibition in intracerebral hemorrhage (ICH). Methods: Three hours after in...
c-Jun N-terminal kinases (JNKs) are a family of protein kinases that play a central role in stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration, cell death, and regulation of cellular senescence. It has been shown that there is a JNK pathway activation aft...