c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase (MAPK) family that activates diverse substrates, such as transcriptional factors, adaptor proteins, and signaling proteins, and has a wide variety of functions in both physiological and pathological conditions. The ...
c-Jun N-terminal kinase signaling pathway in excitotoxic cell death following kainic acid-induced status epilepticus.: Systemic injections of kainic acid (KA) c
Galectin-1 (gal-1), an endogenous-galactoside-binding protein, triggers T-cell death through several mechanisms including the death receptor and the mitochondrial apoptotic pathway. In this study we first show that gal-1 initiates the activation of c-Jun N-terminal kinase (JNK), mitogen-...
c-Jun N-terminal kinases (JNKs) are a family of protein kinases that play a central role in stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration, cell death, and regulation of cellular senescence. It has been shown that there is a JNK pathway activation aft...
Inhibiting c-Jun N-terminal kinase (JNK)-mediated apoptotic signalingpathway in PC12 cells by a polysaccharide (CCP) from Coptis chinensisagainst Amyloid-β (Aβ)-induced neurotoxicityYujuan Lia , Bingmei Wang a , Cong Liu a , Xiaoting Zhu a , Pengqi Zhang a , Hongkui Yu a , Yunqiang...
Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Curcumin, a dietary pigment in curry, suppresses tumor initiation and tumor promotion. Curcumin is also a potent inhibitor for AP-1 and NF-κB activation. ... Chen,Yi-Rong,Tan,... - 《Oncogene》 被引量: ...
2)c-Jun N-terminal proteinkinase (JNK)c-Jun氨基端激酶(JNK) 3)JNKc-jun氨基末端激酶 1.Objective:To study the action mechanism of p,p'-DDE and /or β-BHC onJNKand MAPK signal transduction pathways in rat Sertoli cells in vitro.目的:研究2,2-双-(对氯苯基)-1,1-二氯乙烯(p,p'-DDE)...
Inhibitors of c-jun-N-Terminal Kinase (JNK) have many potential therapeutic indications ranging from neurodegenerative disease, to metabolic disorders, inf... Philip LoGrasso* and Theodore Kamenecka - 《Mini Reviews in Medicinal Chemistry》 被引量: 60发表: 2008年 Mechanisms of minocycline-induced ...
However, the regulation of necroptotic signaling pathway is far less investigated. Here we showed that c-Jun N-terminal kinases (JNK1 and JNK2) displayed kinase-dependent and -independent functions in regulating TNF- and TLRs-mediated necroptosis. We found that RIPK1 and RIPK3 promoted cell-...