当CH键更加acidic,机理比起sear更类似于σ键复分解,值得强调的是,此时可视为CH键断裂成分大于CPd键形成成分(四元环过渡态中),即越缺电子越容易进行反应。 烯烃coupling 两种可能的机理,先活化CHbond或者烯烃,带来区域选择性的区别 有趣的事,关于五六选择性,当以β-H消除脱离循环时,五元环似乎有利,当通过CO插入...
Selectivity is a large issue due to the ubiquitous presence of C–H bonds in all organic molecules (C) H R X R = C or heteroatom X = FG or H (C) R C–H Bond Functionalization/Activation: This Talk ! This talk serves as a very limited survey of the recent literature in C–H ...
其反应条件的优化结果表明:双核金催化剂3c有利于C-C键的还原消除过程,并获得C-H键炔基化产物(5a);而双核金催化剂3h更有利于C-I键的还原消除过程,得到C-H键碘化产物(6a);而单核金Ph3PAuCl会导致产率和选择性明显下降。 在双核金催化剂3c的催化下,作者得到了理想的C-H键炔基化产物(5a-5h)。其中,脂肪族...
待解决 悬赏分:1 - 离问题结束还有 C-H bond functionalization问题补充:匿名 2013-05-23 12:21:38 C-H键的功能化 匿名 2013-05-23 12:23:18 c-h债券functionalization 匿名 2013-05-23 12:24:58 C-H政券functionalization 匿名 2013-05-23 12:26:38 C H 键功能化 匿名 2013-05-23...
Godula, K.,Sames, D.C-H bond functionalization in complex organic synthesis. Science . 2006Godula, K.; Sames, D. C-H bond functionalization in complex organic syn- thesis. Science 2006, 312, 67-72.K. Godula, D. Sames, C-H bond functionalization in complex organic synthesis, Science ...
刘凯博士(现浙江工业大学)为文章第一作者,南京大学谢劲教授为通讯作者。详见:Kai Liu, Tingrui Li, Duan-Yang Liu, Weipeng Li, Jian Han, Chengjian Zhu & Jin Xie*. Dinuclear gold-catalyzed C-H bond functionalization of cyclopropenes.Sci. China Chem.2021, doi/10.1007/s11426-021-1031-x....
As the photobiocatalysis combines the strength of both photocatalysis and biocatalysis, it has therefore become a powerful strategy for the functionalization of the inert C–H bond, which to a large extent meets the criteria of green synthesis in terms of mild conditions, step- and atom-economy,...
此外,该串联反应也可以扩展到芳族骨架的一锅法C-H键酰胺化和羧化。Fl-Hal具有温和的反应条件和高度的区域选择性,因此可用于更复杂的生物活性分子以及药物前体的后期修饰。 Programmable late-stage C-H bond functionalization enabled by integration of enzymes with chemocatalysis...
Diversification of unprotected alicyclic amines via C-H bond functionalization: Decarboxylative alkylation of transient imines Anirudra Paul, Jae Hyun Kim, Scott D. Daniel, and Daniel Seidel* 正文 β-氨基酮化合物广泛出现于有机合成和药物化学中,而对脂环族胺的C-H键官能团化仍然是一个非常活跃的研究...
S. Controlling site selectivity in palladium-catalyzed C–H bond functionalization. Acc. Chem. Res. 45, 936–946 (2012). Article CAS PubMed PubMed Central Google Scholar Zhang, F. & Spring, D. R. Arene C–H functionalisation using a removable/modifiable or a traceless directing group ...