Inside Cover: Catalytic Asymmetric Functionalization of Aromatic C?H Bonds by Electrophilic Trapping of Metal‐Carbene‐Induced Zwitterionic Intermediates (Angew. Chem. Int. Ed. 48/2014)[J] . Shikun Jia,Dong Xing,Dan Zhang,Wenhao Hu.Angew. Chem. Int. Ed. . 2014 (48)...
Recent development of direct asymmetric functionalization of inert C–H bonds Chao Zheng and Shu-Li You This review summarized recent development (contributions after 2009) in the area of direct catalytic asymmetric functionalization reactions of inert C–H bonds...
Recent years have witnessed the growing interest in the remote functionalization of alkenes for it offers a strategy to activate the challenging C–H bonds distant from the initiation point via alkene isomerization/functionalization. However, the catalyt
Fig. 1: α-C−H functionalization of alkyl amines with electrophiles. aN- versus α-C−H allylic alkylation.bAllylic alkylation of alkyl amines through protecting group strategy.cα-C−H Functionalization of activated primary amines through carbonyl catalysis.dThis work: asymmetric α-C−H ...
notably underdeveloped are catalytic asymmetric methods for activating carbon–carbon π-bonds for attack by external nucleophiles. The rich electrophilic addition chemistry of alkenes assures that the development of asymmetric methodology for antarafacial functionalization of alkenes would have significant impact...
Transition metal-catalyzed asymmetric hydrofunctionalizations of unsaturated bonds via 蟺-3 substitution have emerged as a reliable method to construct stereogenic centers, and mainly rely on the use of heteroatom-based or carbon nucleop... MQ Tang,ZJ Yang,ZT He - 《Nature Communications》 被引量...
Recent Progress in Copper-Catalysed C-C Bond Formations via C(sp2)-H Insertions Using Diazo and Related Compounds Site-selective insertion of metal-carbenes via C(sp2)H bond functionalizations is an interesting topic to the synthetic chemistry community. Formations and... S Bera,S Jana,R Samant...
C–H bonds are arguably the most widespread functional groups in organic compounds. Direct C–H functionalization has been a long-term concern for organic synthetic chemists, which could change the operation of synthetic chemistry by shortening the synthesis routes, improving the economy of atoms and...
Transition metal-catalyzed asymmetric hydrofunctionalizations of unsaturated bonds via π-ƞ3 substitution have emerged as a reliable method to construct stereogenic centers, and mainly rely on the use of heteroatom-based or carbon nucleophiles bearing
The enantioselective functionalization of ubiquitous C(sp3)–H bonds is ideally suited for the construction of three-dimensional chiral structures. However, organic molecules often contain multiple C(sp3)–H bonds with a similar energy and steric environment, rendering the simultaneous control of site-...