TH2, and TH17 subsets5. As ILCs are activated by cytokines rather than antigen receptors, this correlation suggests the possibility of T cells having an innate-like capacity. Of note, the concept of antigen-independent “bystander activation...
Cancer-specific T cells are required for effective anti-cancer immunity and have a central role in cancer immunotherapy. However, emerging evidence suggests that only a small fraction of tumor-infiltrating T cells are cancer specific, and T cells that recognize cancer-unrelated antigens (so-called...
Integrase-defective lentiviral vectors encoding cytokines induce differentiation of human dendritic cells and stimulate multivalent immune responses in vitro and in vivo 热度: CD8 T Cells Primed in the Periphery Provide Time-Bound Immune-Surveillance to the Central Nervous System(外周CD8T细胞对中枢神经系统...
Cancer-specific T cells are required for effective anti-cancer immunity and have a central role in cancer immunotherapy. However, emerging evidence suggests that only a small fraction of tumor-infiltrating T cells are cancer specific, and T cells that recognize cancer-unrelated antigens (so-called...
producing T cells (CD4+T = 26.9 ?? 3.6% and CD8+T = 20.3 ?? 2.1%) implying the existence of activated bystander T cells in response to dengue antigen in vitro. These bystander CD4+ and CD8+T cells had similar kinetics to NK cells, appeared after 12 h and were inhibited by anti-...
BystanderCD4Tcellsdonotmediatedemyelinationinmiceinfected withaneurotropiccoronavirus JodieS.Haring a ,StanleyPerlman a,b, * a DepartmentofMicrobiology,UniversityofIowa,IowaCity,IA52242,USA b DepartmentofPediatrics,UniversityofIowa,MedicalLaboratories2042,IowaCity,IA52242,USA Received27November2002;receivedin...
The image shows the infiltration of islet-specific CD8+ T cells (in red) and non-islet-specific CD8+ T cells ('bystanders' in green) in an islet of Langerhans in a mouse pancreas. The pancreatic tissue is visualized in grey by reflected laser light. Credit: Dr. Gustaf Christofferson, Upp...
1. Engager T Cells: A New Class of Antigen-specific T Cells That Redirect Bystander T Cells [J] . Iwahori Kota, Kakarla Sunitha, Velasquez Mireya P., Molecular therapy: the journal of the American Society of Gene Therapy . 2015,第1期 机译:激进性T细胞:重定向旁观者T细胞的一类新的抗原...
The results indicated that bystander CD4 T cells were unable to cause demyelination in MHV-infected mice, despite being recruited into the central nervous system (CNS) and irrespective of activation status. These results suggest that CD4 T cells must recognize antigen in the CNS in order to ...
We found that CD8 memory cells could acquire bystander-activated, cytotoxic CD8 T cell (BA-CTL) function without the involvement of a strong, agonist TCR signal. Brief exposure to IL-12, IL-15, and IL-18 acting directly on the T cells was sufficient to induce cytotoxic potential. Given ...