网络释义 1. 旁观者细胞 ...er effect,BE),发生这种效应的细胞称为旁观者细胞(bystander cells)。 cpfd.cnki.com.cn|基于 1 个网页
With bystander cells present, the velocity and persistence of NK cells were increased, whereas the degranulation of lytic granules remained unchanged. Bystander cell-derived HOwas found to mediate the acceleration of NK cell migration. Using mathematical diffusion models, we confirm that local ...
T cells are the central mediators of both humoral and cellular adaptive immune responses. Highly specific receptor-mediated clonal selection and expansion of T cells assure antigen-specific immunity. In addition, encounters with cognate antigens generate immunological memory, the capacity for long-term,...
The objective of our study was to explore a possible molecular mechanism by which ultraviolet (UV) biophotons could elicit bystander responses in reporter cells and resolve the problem of seemingly mutually exclusive mechanisms of a physical UV signal & a soluble factor-mediated bystander signal. The...
CD8 T Cells Primed in the Periphery Provide Time-Bound Immune-Surveillance to the Central Nervous System(外周CD8T细胞对中枢神经系统的时间免疫监视) 热度: Suwannasaenetal.BMCImmunology2010,11:47 http://.biomedcentral/1471-2172/11/47 RESEARCHARTICLEOpenAccess ...
During murine neurotropic coronavirus infection CD8 T cells are critical anti-viral effectors, while CD4 T cells play a prominent role in the disease and demyelination associated with the infection. The failure of CD8 T cells to control ... T Phares,S Stohlman,C Bergmann - 《Journal of Immun...
"Some had thought bystanders passively add to damage done by specific CTLs but we found the opposite," says first author Gustaf Christoffersson, PhD, a former postdoc in the von Herrath lab. "When bystander cells were present in sufficient amounts, they dampened those inflammatory responses."...
Bystander cells of the tumor microenvironment show evidence of DNA damage and inflammation that can lead to their oncogenic transformation. Mediator(s) of cell–cell communication that brings about these pro-oncogenic pathologies has not been identified.
Cancer-specific T cells are required for effective anti-cancer immunity and have a central role in cancer immunotherapy. However, emerging evidence suggests that only a small fraction of tumor-infiltrating T cells are cancer specific, and T cells that recognize cancer-unrelated antigens (so-called...