These Btk inhibitors are suitable for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. Examples of compounds of formula (D) are: 1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]...
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclos
近日,来自美国国立卫生研究院的Louis M.Staudt团队和德国法兰克福大学的Thomas Oellerich团队在Cancer Cell上在线发表题为Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy的文章,揭示...
In B cells, the key member of this kinase family is Bruton tyrosine kinase (BTK), which is mutated in X-linked agammaglobulinemia. Ibrutinib is a BTK inhibitor that has shown promise in the treatment of B-cell malignancies19; such inhibitors may also be useful in the treatment of ...
Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and functions as an important regulator of cell proliferation and cel... RW Hendriks,S Yuvaraj,LP Kil - 《Nature Reviews Cancer》 被引量: 232发表: 2014年 Bruton's Tyrosine Kinase (BTK) Inhibitors in ...
The Evolving Role of Bruton's Tyrosine Kinase Inhibitors in B Cell Lymphomas Bruton's tyrosine kinase (BTK), a non-receptor tyrosine kinase crucial for B cell development and function, acts downstream of the B cell receptor (BCR) in... S Mehra,M Nicholls,J Taylor - 《International Journal...
Bruton's tyrosine kinase inhibitors Bruton's tyrosine kinase (BTK) is a component of the B-cell receptorsignaling pathwayand has been implicated inWMtumorigenesis. TheMYD88L265Pmutation has been shown to act upstream of BTK and increase the activity ofBTK signaling[43]. In a phase II trial ...
Bruton's tyrosine kinase inhibitors in the treatment of primary central nervous system lymphoma: A mini-review Jing Shen,Jinghua Liu - 《Frontiers in Oncology》 - 2022 - 被引量: 0 SUBSTITUTED 1H-IMIDAZO [1, 2-B] PYRAZOLE-3-CARBOXAMIDE...
Described herein are inhibitors of Bruton's tyrosine kinase (Btk). Also described herein are irreversible inhibitors of Btk. Further described are irreversible inhibitors of Btk that form a covalent bond with a cysteine residue on Btk. Further described herein are irreversible inhibitors of other tyro...
Bruton's Tyrosine Kinase Inhibitors: Approaches to Potent and Selective Inhibition, Preclinical and Clinical Evaluation for Inflammatory Diseases and B Cel... Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and...