本文描述了激酶抑制剂化合物,此类抑制剂的合成方法和在疾病的治疗中使用此类抑制剂的方法. This article describes the kinase inhibitor compounds, synthetic methods such inhibitors and methods of using such inhibitors in the treatment of disease. 本文进一步描述了用于测定包括激酶在内的蛋白质的适当抑制剂的...
Bruton’s tyrosine kinase (BTK) inhibitor is a promising novel agent that has potential efficiency in B-cell malignancies. It took approximately 20 years from target discovery to new drug approval. The first-in-class drug ibrutinib creates possibilities
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英文名称Bruton′s Tyrosine Kinase Inhibitor III 储存温度-20°C储存 运输条件超低温冰袋运输 产品介绍 布鲁顿酪氨酸激酶抑制剂III是细胞可渗透的吡咯并吡啶基-丙烯酰基化合物,它是Btk的高效,选择性和不可逆的抑制剂(IC | 50 | = 720 pM),并且仅在以下位置影响Lyn,Lck和Itk活性更高的浓度(IC | 50 | = ...
Bruton's tyrosine kinase (BTK) is a non-receptor protein kinase that plays a crucial role in various biological processes, including immune system function and cancer development. Therefore, inhibition of BTK has been proposed as a therapeutic strategy for various complex diseases. In this study, ...
In B cells, the key member of this kinase family is Bruton tyrosine kinase (BTK), which is mutated in X-linked agammaglobulinemia. Ibrutinib is a BTK inhibitor that has shown promise in the treatment of B-cell malignancies19; such inhibitors may also be useful in the treatment of ...
深入研究「Bruton's tyrosine kinase (Btk) inhibitor ibrutinib suppresses stem-like traits in ovarian cancer」主題。共同形成了獨特的指紋。 引用此 APA Standard Harvard Vancouver Author BIBTEX RIS Zucha, M. A., Wu, A. T. H., Lee, W. H., Wang, L. S., Lin, W. W., Yuan, C...
Targeted drugs, cell Lines, and culture Three target drugs including EGFR inhibitor Gefitinib (ZD1839), second-generation BTK inhibitor Acalabrutinib (ACP-196), and third-generation epidermal growth factor receptor tyrosine kinase inhibitor Osimertinib (AZD9291) were purchased from Selleckchem, Inc (Ho...
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. J Clin Oncol. 2013;31(1):88-94.Advani RH, Buggy JJ, Sharman JP, Smith SM, Boyd TE, Grant B, et al. Bruton tyrosine kinase inhibitor ibrutinib (PCI-...
Bruton's tyrosine kinase (Btk) plays an important role in the pathophysiology of local inflammation in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). A unique t