Iyer, Raman MahadevanLaine, Dramane IbrahimLopez-tapia, Francisco JavierPhillips, Jonathan E.Stevenson, Christopher
The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same. Inventors: Bui, Minna (Oakland, CA, US) Conlon, Patrick (Wakefield, MA, US) Cuervo, Julio H. (Arlington, MA, US) Erlanson, Daniel A. (San Francisco, CA, US)...
BTK is a cytoplasmic, non-receptor tyrosine kinase that transmits signals from a variety of cell-surface molecules, including the B-cell receptor (BCR) and tissue homing receptors. Genetic BTK deletion causes B-cell immunodeficiency in humans and mice, making this kinase an attractive therapeutic ...
但是,ABC型DLBCL对BTK抑制剂反应的分子机制,尤其是MCD型DLBCL患者表现出的如此特殊的反应的原因仍未可知。 近日,来自美国国立卫生研究院的Louis M.Staudt团队和德国法兰克福大学的Thomas Oellerich团队在Cancer Cell上在线发表题为Response to Br...
Bruton's tyrosine kinase inhibitors in the treatment of multiple sclerosis Shulga, Olga,Chabanova, Anna,Kotsiuba, Oleksandra - 《Postepy Psychiatrii I Neurologii》 - 2023 - 被引量: 0 Bruton's tyrosine kinase inhibitors in the treatment ...
BPG致力于知识的发现和传播 Bruton’s tyrosine kinase inhibitors in primary central nervous system lymphoma: New hopes on the horizon Leonardo S Lino-Silva, Sabrina B Martínez-Villavicencio, Luisa Fernanda Rivera-Moncada Leonardo S Lino-Silva, Sabrina B Martínez-Villavicencio, Luisa Fernanda Rivera-...
Keywords:Primary central nervous system lymphoma;Zanubrutinib;Bruton’s tyrosine kinase;Prognosis;Myeloid differentiation primary response 88 gene;Cluster of differentiation 79B gene Core Tip:The combination of zanubrutinib with high-dose methotrexate shows promise as a therapeutic approach for primary ce...
Bruton's Tyrosine Kinase Inhibitors: Approaches to Potent and Selective Inhibition, Preclinical and Clinical Evaluation for Inflammatory Diseases and B Cel... Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and...
Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and functions as an important regulator of cell proliferation and cell survival in various B cell malignancies. Small-molecule inhibitors of BTK have shown antitumour activity in animal models and, recently, ...
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclos