A study led by researchers from the University of Arizona Cancer Center at UArizona Health Sciences identified a biological mechanism that could lead to more effective treatments for breast cancer that has metastasized to the brain. By studying the metabolic differences between primarybreast cancercells...
The researchers' next step is to initiate a collaboration with CAR T-cell experts to further understand how CAR T-cell therapy can be targeted to IL13Ra2. Eventually, Cittelly hopes to see clinical trials for patients withbreast cancerthat has metastasized to the brain, as they are currently...
In this review, we discuss the barriers and challenges associated with employing systemic therapy to treat brain metastases. We also provide an overview of current systemic therapy used as standard of care in all subtypes of breast cancer that have metastasized to the brain, as well as describe ...
Approximately one-tenth of all patients with advanced breast cancer develop brain metastases resulting in an overall survival rate of fewer than 2 years. The challenges lie in developing new approaches to treat, monitor, and prevent breast cancer brain metastasis (BCBM). This review will provide ...
A case of breast cancer metastasized to the brain 28 years after mastectomy in a 74-year-old woman is reported. The patient had undergone a mastectomy because of right breast cancer at the age of 46. Histopathological diagnosis of the tumor was invasive ductal carcinoma papillo-tubular type, ...
I stopped by Mother’s house, She’d wanted to live at home to look after herself while she could...(在她被确诊后不久,我去了母亲的家。她想在力所能及的时候住在家里照顾自己……)”及第四段“As her health worsened, Mother eventually decided to stay with me in my house on the weekends...
Data derived from the Metastatic Colorectal Cancer MSK database [17], n = 1134 total samples. MUT: mutated; NS: not sequenced; WT: wild type. As for the abovementioned, the development of targeting agents in the metastatic setting has lagged behind that of the same agents against primary ...
Breast cancer that has metastasized to the brain presents difficult clinical challenges. This diagnosis comes with high mortality rates, largely due to com... DH Murrell,PJ Foster,AF Chambers - 《Journal of Molecular Medicine》 被引量: 28发表: 2014年 加载更多来源...
内容提示: LETTERSGenes that mediate breast cancer metastasisto the brainPaulaD.Bos 1 ,XiangH.-F.Zhang 1 ,CristinaNadal 1 {,WeipingShu 1 ,RogerR.Gomis 1 {,DonX.Nguyen 1 ,AndyJ.Minn 2 ,Marc J. van de Vijver 3 , William L. Gerald 4 , John A. Foekens 5 & Joan Massague ´ 1...
"QBS72S has shown promise in preclinical studies due to its targeted mechanism of action. I look forward to the opportunity to investigate this compound for patients in need." When metastasized to the brain, most of the treatments for patients with breast cancer have limited efficacy. This...