Purpose of ReviewBrain metastasis is a significant cause of mortality in breast cancer patients and treatment options are limited. This article will focus on the dynamic intercellular communication between metastatic cancer cells, the tumor microenvironment, and neighboring brain cells to breach the brain...
doi:10.1038/nrc2678Sarah SetonRogersNature Reviews Cancerbreast cancer metastasis to the brain. Nature 459, 1005-1009. Broxterman, H.J., Gotink, K.J., and Verheul, H.M. (2009). Understanding the causes of
The molecular basis for breast cancer metastasis to the brain is largely unknown1,2. Brain relapse typically occurs years after the removal of a breast tumour2,3,4, suggesting that disseminated cancer cells must acquire specialized functions to take over this organ. Here we show that breast canc...
内容提示: LETTERSGenes that mediate breast cancer metastasisto the brainPaulaD.Bos 1 ,XiangH.-F.Zhang 1 ,CristinaNadal 1 {,WeipingShu 1 ,RogerR.Gomis 1 {,DonX.Nguyen 1 ,AndyJ.Minn 2 ,Marc J. van de Vijver 3 , William L. Gerald 4 , John A. Foekens 5 & Joan Massague ´ 1...
The investigation paid off: The researchers grew breast-to-brain metastasis cells in the lab to study their relationship to the NMDAR. And, sure enough, the cells were found to co-opt the entire system by which the NMDAR relays its effects to neurons—what biologists refer to as a "signali...
MetastasisBlood VesselsTumor Cell ProliferationA metastatic cascade appears to operate as a non-random predetermined system of selective advantage implicating initially a sieving effect by the first capillary beds in an organ of spread. A seed-soil predilection appears to constitute a released system of...
Blood-Brain Barrier Integrity and Breast Cancer Metastasis to the Brain英文文献资料.doc,SAGE-HindawiAccesstoResearch PathologyResearchInternational Volume2011,ArticleID920509,12pages doi:10.4061/2011/920509 ReviewArticle Blood-BrainBarrierIntegrityand Br
Brain metastasis is an increasingly common complication for breast cancer patients; approximately 15– 30% of breast cancer patients develop brain metastasis. However, relatively little is known about how these metastases form, and what phenotypes are ch
Breast cancer spreads to other organs like brain, lung and bone. The metastasis of breast cancer to the brain is a terminal disease and the deadliest complication. There is a lack of targeted therapies for breast cancer brain metastases, said first study author Deepak Kanojia, research associate...
Abstract A21: Human breast-to-brain metastases display GABAergic properties in the neural niche The high frequency and poor prognosis of breast-to-brain metastasis (BBM) indicates the need for detailed studies of metastatic breast cancer cells, the br... J Neman,J Termini,CM Kowolik,... -...