Phylogenetic analyses in patients with cancer and xenograft models highlight heterogeneity within individual CTC clusters, providing insights into clonal dynamics during metastasis. David Gremmelspacher Johannes
Cancer metastasis is a complex, multistage process, which eventually causes tumor cells to colonize and grow at the metastatic site16. Exosomes derived from tumors and stromal cells have been involved in all stages of cancer metastasis. In addition to the different types of substances loaded in ex...
Breast Cancer Research . 2010Zecchin D,Bardelli A.Tracking the genomic evolution ofbreast cancer metastasis.Breast Cancer Research. 2010Zecchin D, Bardelli A. Tracking the genomic evolution of breast cancer metastasis. Breast Cancer Res 2010; 12: 302....
Breast cancer starts as a local disease, but it can metastasize to the lymph nodes and distant organs. At primary diagnosis, prognostic markers are used to assess whether the transition to systemic disease is likely to have occurred. The prevailing model of metastasis reflects this view — it ...
[1].Metastasisaccounts for approximately 90% of cancer associated deaths when compared toprimary tumours. Metastatic/advanced stage breast cancer commonly called as stage IV breast cancer, wherein the cancercellsinvade distant sites beyond the breast in proximity to auxiliary lymph nodes[2]. ...
Low grade High frequency of diploid/CIN (65%).Moderate aneuploid/CIN+ status (28%) Endocrine therapy sensitive, poor response to chemotherapy.Recurrence risk is low.Metastasis 2, 3, 4, 5, 6, 7, and 8 [54,57–63] Luminal B(∼20–25%) ER (+) and/or PgR (+) (low expression)...
A research article published in Nature Communications identifies a new mechanism of breast cancer metastasis. Scientists at Queen Mary University of London (QMUL) have uncovered a new mechanism which makes breast cancer cells move and invade the body, a discovery which could shed light on how to...
U.S. researchers identify gene in breast cancer pathway (File photo) The findings could help predict whether breast tumors will metastasize and also reveal potential drug targets for preventing metastasis, the university announced here on Tuesday. ...
Circulating cell-free DNA (cfDNA) has recently been recognized as a resource for biomarkers of cancer progression, treatment response, and drug resistance. However, few have demonstrated the usefulness of cfDNA for early detection of cancer. Although abe
Figure 2. RKIP signaling pathway regulates breast cancer metastasis to the bone. Highlighted with light blue rectangles are the components of the pathway that are also part of the RPMS. Highlighted with light blue ovals are the meta-genes that were added to the signaling pathway to make the RP...