Breast carcinoma is the most common cancer of women. Bones are often involved with breast carcinoma metastases with the resulting morbidity and reduced qua
Invasive breast cancer tends to metastasize to lymph nodes and systemic sites. The management of metastasis has evolved by focusing on controlling the growth of the disease in the breast/chest wall, and at metastatic sites, initially by surgery alone, then by a combination of surgery with radiati...
While the interactions of cancer cells with resident bone cells at the established metastatic gross lesions are well-studied, the preclinical events that underlie the progression of disseminated tumor cells into micrometastases and then into clinically-overt macrometastases are just starting to be ...
Also, I am writing a blog of my own personal journey. You will read about me in the book, and at the time of publication I was deemed cancer free. However, since then my cancer returned. In December 2016 I was diagnosed with Stage IV Metastatic Breast Cancer. They have found mets to...
The majority of metastatic breast cancer occurs as a relapse of a previously treated early stage breast cancer, with tumor most likely recurring in the bone, liver, and lungs. The risks of recurrence vary based on tumor characteristics. The process of metastasis is complex, with cells undergoing...
Metastatic/advanced stage breast cancer commonly called as stage IV breast cancer, wherein the cancer cells invade distant sites beyond the breast in proximity to auxiliary lymph nodes [2]. Most often, it spreads to bone, liver, lungs, brain and other organs. Sometimes, metastatic cancer...
cancer20,23. Hence, dissemination to the large majority of sites was consistent with monoclonal seeding (see Supplementary Fig.7). However, 2/12 samples, one in the liver and one in the ovary were polyclonal in origin, suggesting exchange of seeding between these two metastatic sites. ...
Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or
Finally, metastatic breast cancers showed an increase in mutational burden and clonal diversity compared to early breast cancers. Thus, the genomic landscape of metastatic breast cancer is enriched in clinically relevant genomic alterations and is more complex than that of early breast cancer. The ...
The metastatic spread of cancer is achieved by the haematogenous dissemination of circulating tumour cells (CTCs). Generally, however, the temporal dynamics that dictate the generation of metastasis-competent CTCs are largely uncharacterized, and it is often assumed that CTCs are constantly shed from ...