Fig. 4: ZEB1 reprograms the ERα transcriptome to promote an EMT phenotype of breast cancer cells. a Venn diagram showing the overlap of the differentially expressed genes for MCF7-V-ZEB1 cells with (+DOX) or without (−DOX) ZEB1 expression in presence of indicated treatments. Fold changes...
We then used this dataset to train deep CNN models for cell image classification. These trained classifiers learned to label cancer cells as live or dead without staining and using only bright-field images as input. A diagram of the presented workflow is shown in Fig. 1a. We additionally ...
Both miR-29a and miR-29b are considered tumor suppressors in breast cancer and their repression results in in cancer stem cell expansionin vitro57. Progestins repress miR-29a and miR-29b in ER+/PR+ breast cancer cells58and “PR action in breast cancer: stimulation of metastasis” was identif...
Raman spectra of breast cancer cells treated by the HER2 IgY-SWNT complex. A 785 nm laser diode was used for excitation at 1-25 mW through a 10× objective lens on randomly selected cells. Raman spectra of a representative cell from each sample are shown. Blue line, SK-BR-3 cell treat...
Basal-like and luminal breast cancers have distinct stromal–epithelial interactions, which play a role in progression to invasive cancer. However, little is known about how stromal–epithelial interactions evolve in benign and pre-invasive lesions. To s
We found that 7 DEG were overlapped of which six are reported in the database. This data highlight the diverse gene networks and pathways in MCF-7 and MDA-MB-231 human breast cancer cell lines treated with dioscin.Previous article in issue Next article in issue...
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with higher aggressiveness and poorer outcomes. Recently, long non-coding RNAs (lncRNAs) have become the crucial gene regulators in the progression of human cancers. However, the function
Consequently, a particular cellular task (cell proliferation, cell division) rarely involves a single gene [2]. Cancer-specific disturbance in one gene can channelize to other genes or gene products [3,4]. Moreover, similar to other cancers, pathogenesis of breast cancer involves various phases ...
Lacking of both prognostic biomarkers and therapeutic targets, triple-negative breast cancer (TNBC) underscores pivotal needs to uncover novel biomarkers and viable therapies. MicroRNAs have broad biological functions in cancers and may serve as ideal bi
Diagram of breast cancer pathological image classification using MSMV-PFENet. (a) KREM. (b) PFENet. (c) FDNet. MSI: multi-scale input; PIL: preprocessing input layer; CB: convolution block; AAP: adaptive average pooling; D: dimensions; MV: majority vote. Full size image The proposed MVM...