By virtue of their tumorigenic potential and drug resistance phenotype, CSCs have emerged as one of the potential therapeutic targets for breast cancer treatment. In this review, we have discussed the biology of CSCs and their implications in angiogenesis, metastasis and drug resistance. In addition...
Schatten H: Cell and molecular biology of breast cancer. Humana Press, 2013.Ambrosino, C. T., R; Nassa, G.; Cirillo, C.; Weisz, A., in: Schatten, H. (Ed.), Cell and Molecular Biology of Breast Cancer, New York 2013, pp. 149-174....
New insights into cell biology, disease etiology, drug response, molecular resolution, disease taxonomy, the identification of heterotypic cell interactions, and the determination of cell differentiation events in breast cancer are now achievable [190]. Fathi et al. [193] highlight the use of ...
ResearchOpen Access03 Jan 2025Nature Cancer P: 1-19 Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions Multi-ancestry fine-mapping of breast cancer susceptibility regions identifies candidate causal variants and prioritizes likely effector gene...
Tang Single-cell sequencing in stem cell biology Genome Biol., 17 (2016), p. 71 Google Scholar [189] Y.-C. Chen, S. Sahoo, R. Brien, S. Jung, B. Humphries, W. Lee, Y.-H. Cheng, Z. Zhang, K.E. Luker, M.S Wicha Single-cell RNA-sequencing of migratory breast cancer ...
Male Breast Cancer Research Breast Cancer and Immunology Breast Cancer Management Breast Cancer Nursing Radiology Epidemiology of Breast Cancer and Risk Factors Inflammatory Breast Cancer Mammography Diet and Lifestyle Effects on Breast Cancer Breast Cancer and Cell Biology Breast Cancer Clini...
The phenotypic and functional differences between cells that initiate human breast tumors (cancer stem cells) and those that comprise the tumor bulk are difficult to study using only primary tumor tissue. We embarked on this study hypothesizing that breast cancer cell lines would contain analogous ...
IL-6 mainly promotes the expression of multiple genes through STAT3, thus regulating breast cancer drug resistance (Fig. 1a). IL‑8 Interleukin-8 (IL-8), also known as chemokine CXCL8, is a cytokine secreted by a wide range of cell populations. IL-8 has cellular chemotax...
Nature Cell Biology volume 26, pages 1597–1612 (2024)Cite this article 4317 Accesses 4 Altmetric Metrics details Abstract Bone metastasis is a lethal consequence of breast cancer. Here we used single-cell transcriptomics to investigate the molecular mechanisms underlying bone metastasis colonization—...
Interestingly, numerous studies demonstrated that cytokines and adipokines such as IL-6, IL-1β, TNFα and Leptin are major factors in breast cancer progression6. Thus, adipose tissue may be an important modulator of breast cancer cell biology. The systemic effects of obesity on cancer are ...