In breast cancer, malignant cells disseminate through lymphatic or hematogenous routes to distant organs. Over the last decades, the 5-year survival of breast cancer has increased due to early screening and advanced local and systemic treatments. Understanding the fundamental biology underlying the ...
Here, we discuss the molecular basis of breast cancer metastasis and the challenges in personalization of treatment. The instability of metastatic tumors remains a leading obstacle to personalization, because information from a patient's primary tumor may not accurately reflect the metastasis, and one ...
New molecular insights challenge the traditional model of metastasis, and indicate that the metastatic capacity of breast tumours is an inherent feature, and not necessarily a late, acquired phenotype. Local breast cancer might have a 'non-metastatic, good-prognosis' stem cell of origin; metastasizin...
We conclude that Cil-L reduced metastasis by restricting the aggregability of mouse platelets, which probably prevents the interaction between circulating 4T1 tumor cells and platelets, making the Cil-L a useful tool for the inhibition of breast cancer metastasis in mice. 展开 关键词:...
A multi-OMICS analysis may indeed capture the complex picture of cell plasticity and metastasis in detail, when compared to conventional genomics studies. 3. Which multi-OMICS data layers should we consider? The logical answer to this question would of course be: genome, epigenome, transcriptome,...
Central nervous system (CNS) metastasis was noted in 309 patients of 1044 autopsy cases of breast carcinoma. The brain was involved in 193 cases, and crani... Yoshiaki,Tsukada,MD,... - 《Cancer》 被引量: 420发表: 1983年 Central nervous system metastasis in breast cancer Background and pu...
Breast cancer (BC) is the most frequently invasive malignancy and the leading cause of tumor-related mortality among women worldwide. Cancer metastasis is a complex, multistage process, which eventually causes tumor cells to colonize and grow at the meta
Breast CSCs are generated when breast cancer cells undergo epithelial-mesenchymal transition resulting in aggressive, highly metastatic, and invasive phenotypes that exhibit resistance towards chemotherapeutics. Metastasis, a phenomenon that aids in the migration of breast CSCs, occurs through any of three ...
We report that first case of metastasis to the body of t... WT Yap,JP Richie - 《Journal of Urology》 被引量: 116发表: 1980年 Metastatic prostate cancer masquerading clinically and radiologically as a primary caecal carcinoma Background Prostatic carcinoma is the second most common cause of...
Breast cancer cells preferentially spread to bone. Bone metastases are currently incurable and therefore better treatments need to be developed. Metastasis is an inefficient, multi-step process. Specific aspects of both breast cancer cells and the bone microenvironment contribute to the development of bo...