At 15 years, the incidence was significantly lower in the group treated by post-op RT + poly A – poly U (42% metastasis-free survival in the RT group and 29% in the CT group p=0.03). This result seems to be due mostly to lower incidence of local recurrence. But even in patients...
and the role of HMGB1 in breast cancer remains controversial3. According to the GEO database, among all of the patients initially diagnosed with breast cancer, patients with high HMGB1 expression are more likely to have breast cancer metastasis, especially in basal-like breast...
Our results show that the porous PDMS drug delivery system effectively inhibits triple negative breast cancer recurrence and metastasis assessment. Thus, no tumor regrowth was observed (after 6 weeks of drug elution) in the groups that had the drug-eluting devices. In contrast, there was tumor re...
To assess proportions of metastatic recurrence in women initially diagnosed with non-metastatic breast cancer by stage at diagnosis, breast cancer subtype, calendar period and age. A systematic search of MEDLINE and Web of Science databases (January 2010
Tamoxifen (TAM) is the most commonly used adjuvant endocrine drug for hormone receptor-positive (HR+) breast cancer patients. However, how to accurately evaluate the risk of breast cancer recurrence and metastasis after adjuvant TAM therapy is still a major concern. In recent years, many studies...
Our therapeutic strategy may provide a clue for the clinical management of breast cancer and also its metastasis and recurrence. 2. Materials and methods 2.1. Synthesis and characterization of CPT conjugated HA (CPT-HA) Hyaluronic acid (HA, MW: 32 k) was purchased from Zhenjiang Dong Yuan ...
Gao, X., Zhang, M., Tang, Y., & Liang, X. (2017). Cancer cell dormancy: Mechanisms and implications of cancer recurrence and metastasis.OncoTargets and Therapy,10(null), 5219–5228.https://doi.org/10.2147/OTT.S140854 ArticlePubMedPubMed CentralGoogle Scholar ...
We offer up an alternative paradigm that suggests that not all metastases are due to cellular dissemination with late onset local and distant recurrence resulting from a transfection phenomenon, whereby subcellular particles shed by the primary cancer cell are taken up by wandering cells of the ...
Cancer is subject to immune surveillance, and HIV infection dampens immune capacity, but HIV-induced immune alterations in patients with breast cancer is still unclear. Here the authors profile women living with HIV to find increased CD8 T cell tumor infiltration, enhanced checkpoint molecular express...
New molecular insights challenge the traditional model of metastasis, and indicate that the metastatic capacity of breast tumours is an inherent feature, and not necessarily a late, acquired phenotype. Local breast cancer might have a 'non-metastatic, good-prognosis' stem cell of origin; metastasizin...