在病理组织学角度,约有60%～80%的BRCA1m乳腺癌为三阴性乳腺癌(triple-negative breast cancer,TNBC),即激素受体表达缺失或极低,组织学分级较高,增殖指数较高等,而超过75%的BRCA2m乳腺癌为激素受体阳性乳腺癌。 目前,关于gBRCA1/2m乳腺癌患者的生存预后是...
根据美国国立卫生研究院(National Institution of Health,NIH)的最新数据,晚期乳腺癌患者5年生存率只有27%,而对于转移性三阴性乳腺癌(triple-negative breast cancer,TNBC)患者,这一数值更是低至11%。 随着治疗手段的革新,晚期乳腺癌患者迎来了越来越多样化的治疗选择,其中靶向治疗更是引人瞩目。除了广为人知的HER-2...
此为记! 初夏时节,肿瘤外科的年轻人们阅读分享文献的热情不减,今天和我们分享文献的是我们的魏群博士,分享的文献是“Carboplatin in BRCA1/2-mutated and triple negative breast cancer BRCAness subgroups: the TNT Trial”,发表于2018年5月N...
3.Giampaolo Bianchini, et al. Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease. Nat Rev Clin Oncol. 2016 November ; 13(11): 674–690. 5.Savas P, et al. Clinical relevance of host immunity in breast cancer: from TILs to the clinic. Nat Rev Clin Oncol...
Villarreal-Garza C, Weitzel JN, Llacuachaqui M, Sifuentes E, Magallanes-Hoyos MC, Gallardo L, et al. The prevalence of BRCA1 and BRCA2 mutations among young Mexican women with triple-negative breast cancer. Breast Cancer Res Treat. 2015;150(2):389-94....
Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA Authors - Limei Ji View Article human WB Pharmacol Res FDI-6 and olaparib synergistically inhibit the growth of pancreatic cancer by repressing BUB1, BRCA1 and CDC25A signaling pathway...
Keywords:Triplenegativebreastcancer:CK5/6:CK14;CK17;EGFR:BRCAl:BRCA2 乳腺癌是女性最常见的恶性肿瘤,传统的l临床分 期是较成熟的预后评估指标。“三阴性乳腺癌”是近 年来提出的一种特殊分子类型的乳腺癌,即ER、PR、 HER-2均为阴性。此类型乳腺癌在所有乳腺癌中占 ...
It is found that FGF/FGFR2 signaling drives the development of triple-negative breast cancer accompanied by epithelial-mesenchymal transition that is regulated by FGFR2-STAT3 signaling. It is demonstrated that FGFR2 suppresses BRCA1 via the ERK-YY1 axis and promotes tumor progression. BRCA1 knock...
Germline mutations in the BRCA1 and BRCA2 genes account for 20–25 % of inherited breast cancers and about 10 % of all breast cancer cases. Detection of BRCA mutation carriers can lead to therapeutic interventions such as mastectomy, oophorecto
[18]Yao-Lung K,Dar-Ren C,Tsai-Wang C.Clinicopathological features of triple-negative breast cancer in Taiwanese women[J].Int J Clin Oncol,2011,16(5):500-505. [19]Anders C K,Zagar T M,Carey L A.The management of early-stage and metastatic triple-negative breast cancer:a review[J].H...