Pathogenic mutations in BRCA1 and BRCA2 genes markedly increase the risk of breast cancer and other cancers such as ovarian/fallopian tube, pancreatic, prostate, and melanoma. Patients with BRCA1 mutations have a slightly higher lifetime risk of breast cancer than BRCA2 mutation carriers, and ...
BRCA2-mutated carriers have a high lifetime risk of breast cancer (BC), an early age of onset, and an increased risk of other cancers (including ovarian, pancreatic, and prostate cancer). Almost 70–80% of BRCA2-mutated BC are estrogen receptor (ER)-positive, which is a particular type...
cancer4. The risk of developing pancreatic cancer or prostate cancer is also substantially increased1,3. Pathogenic variants are now used for the clinical management of carriers through prevention, screening and cancer treatment. However, the interpretation and classification of more than 5,000 ...
Among female BRCA1 mutation carriers, the lifetime risk of breast cancer has been estimated at between 65 and 85%, and the risk of ovarian cancer between 39 and 63% [3–5]. For BRCA2 mutation carriers, the lifetime risk for breast cancer ranges from 45 to 85%, and between 11 and ...
The estimated lifetime risk of prostate cancer is reported to be at ~14–18 %, with a median age of 66 years at diagnosis [1]. Genetic factors contribute to at least 40 % of all PC in patients under 50 [2]. * Correspondence: h.leung@beatson.gla.ac.uk †Equal contributors 1...
The lifetime breast cancer risk among carriers of BRCA2 mutations can exceed 80% (Ford et al., 1998, Narod, 2002). Mutations in BRCA2 also contribute to the development of pancreatic, prostate, and male breast cancers (Couch et al., 1996, Lowenfels and Maisonneuve, 2005, Simard et al....
INTRODUCTION Germline mutations of BRCA2 confer a high lifetime risk of female breast cancer and are associated with an increased risk of male breast cancer, ovarian cancer, prostate cancer and pancreatic cancer [1–7]. The gene is thought to behave as a tumour suppressor; tumours from ...
While the retrospective studies have suggested that the cancer risk might vary between BRCA1 and BRCA2 mutation carriers [5], recent prospective studies have shown that the lifetime breast cancer risk is similar for both genes ranging from 55 to 72% [6,7,8]. For Korean breast cancer ...
The lifetime risks of breast cancer in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations. Cancer Epidemiol Biomark Prev. 2001 May;10(5):467–73. 9. Mavaddat N, Peock S, Frost D, Ellis S, Platte R, Fineberg E, et al. Cancer risks for BRCA1 and BRCA2 mutation carriers: ...
Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 have been proven to predict a drastically increased lifetime risk of breast and ovarian cancers in the individuals who carry them. A number of studies have shown that the third most common cancer associated with these mutations is...