BRCA2-mutated carriers have a high lifetime risk of breast cancer (BC), an early age of onset, and an increased risk of other cancers (including ovarian, pancreatic, and prostate cancer). Almost 70–80% of BRCA2-mutated BC are estrogen receptor (ER)-positive, which is a particular type...
Functional analysisRecombination reactionsMonoclonal antibodiesGermline mutations in the BRCA2 gene lead to an increased lifetime risk for breast and ovarian cancer, and pancreatic, prostate, and male breast cancers. Although the BRCA2 protein has been reported to play a role in DNA repair, the ...
Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 have been proven to predict a drastically increased lifetime risk of breast and ovarian cancers in the individuals who carry them. A number of studies have shown that the third most common cancer associated with these mutations is...
Discussion In addition to being at risk for breast and ovarian cancers, heterozygous BRCA2 mutation carriers are at an increased risk for other adult-onset malignant neoplasms, including pancreatic cancer, prostate cancer, and melanoma.6 The increased non–Hodgkin lymphoma risk observed among BRCA2 ...
INTRODUCTION Germline mutations of BRCA2 confer a high lifetime risk of female breast cancer and are associated with an increased risk of male breast cancer, ovarian cancer, prostate cancer and pancreatic cancer [1–7]. The gene is thought to behave as a tumour suppressor; tumours from ...
The lifetime breast cancer risk among carriers of BRCA2 mutations can exceed 80% (Ford et al., 1998, Narod, 2002). Mutations in BRCA2 also contribute to the development of pancreatic, prostate, and male breast cancers (Couch et al., 1996, Lowenfels and Maisonneuve, 2005, Simard et al....
Among female BRCA1 mutation carriers, the lifetime risk of breast cancer has been estimated at between 65 and 85%, and the risk of ovarian cancer between 39 and 63% [3–5]. For BRCA2 mutation carriers, the lifetime risk for breast cancer ranges from 45 to 85%, and between 11 and ...
Objective: Women who are carriers of BRCA gene mutations have an elevated lifetime risk of developing breast or ovarian cancer. Although a number of risk-r... S Wainberg,J Husted - 《Cancer Epidemiol Biomarkers Prev》 被引量: 163发表: 2004年 Associations of high-grade prostate cancer with ...
of Pathology, University Hospital, Reykjavik, Iceland; 6Faculty of Medicine, University of Iceland, Reykjavik, Iceland A T – C polymorphism in the promoter region of the CYP17 gene has been associated with male and female breast cancer risk as well as early-onset familial breast cancer. The...
damage, controlling the “cell cycle,” and regulating the expression of various other genes throughout the body. However,certain variations in these genes have been associated with increased risk of several different types of cancer— especially breast cancer, ovarian cancer, and prostate cancer [3...