Functional analysisRecombination reactionsMonoclonal antibodiesGermline mutations in the BRCA2 gene lead to an increased lifetime risk for breast and ovarian cancer, and pancreatic, prostate, and male breast cancers. Although the BRCA2 protein has been reported to play a role in DNA repair, the ...
Germline mutations in theBRCA2tumour suppressor are associated with both an increased lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression, here we profile the genomes ... RA Taylor,M Fraser,J Livingstone,... - 《Nature Communi...
The role of BRCA1 and BRCA2 in prostate cancer One of the strongest risk factors for prostate cancer is a family history of the disease. Germline mutations in the breast cancer predisposition gene 2 (BR... E Castro,R Eeles - 《Asian Journal of Andrology》 被引量: 85发表: 2012年 ...
Several genes that are associated with a high lifetime risk of breast cancer in women have been identified during the past decade. One of these, BRCA2, has also been shown to confer a significant risk of breast cancer in men, and a recent study found the risk of breast cancer in male ...
In particular, BRCA2 loss-of-function pathogenic variants are associated with a 69% lifetime risk of developing breast cancer2 and a 15% risk of developing ovarian cancer4. The risk of developing pancreatic cancer or prostate cancer is also substantially increased1,3. Pathogenic variants are now...
The estimated lifetime risk of prostate cancer is reported to be at ~14–18 %, with a median age of 66 years at diagnosis [1]. Genetic factors contribute to at least 40 % of all PC in patients under 50 [2]. * Correspondence: h.leung@beatson.gla.ac.uk †Equal contributors 1...
This study examines for the first time the characteristics of hereditary breast cancer in Puerto Rico and assesses the accuracy of existing genetic risk assessment tools in that population. This data is expected to contribute to providing accurate and efficient tools for the clinical management of ...
The lifetime risk of breast cancer may approach 80-90% in women who have germline mutations of either of two genes, BRCA1 or BRCA2. A single BRCA1 mutation... S Neuhausen,T Gilewski,L Norton,... - 《Nature Genetics》 被引量: 523发表: 1996年 Analysis of cancer risk and BRCA1 and...
lifetime risk of developing a malignancy such as Breast Cancer (BrCa), Ovarian Cancer (OvCa), Prostate Cancer (PrCa), and Pancreatic Cancer (PaCa) compared to the general population [3,4,5,6,7]. Interestingly, the risk probability of carcinogenesis varies and depends on the type and ...
INTRODUCTION Germline mutations of BRCA2 confer a high lifetime risk of female breast cancer and are associated with an increased risk of male breast cancer, ovarian cancer, prostate cancer and pancreatic cancer [1–7]. The gene is thought to behave as a tumour suppressor; tumours from ...