BRCA1和BRCA2是乳腺癌易感基因(breast cancer susceptibility gene,BRCA),是重要的抑癌基因,其编码产物参与DNA损伤同源性重组修复(homologous recombination repair)。同源重组缺陷(homologous recombination deficiency,HRD)可以由BRCA1/2基因突变导致,使得基因组不稳定...
6.Schayek H, Haugk K, Sun S, True LD, Plymate SR, Werner H. Tumor Suppressor BRCA1 is Expressed in Prostate Cancer and Control IGF1-R Gene Transcription in an Androgen Receptor-Dependent Manner. Clin Cancer Res (2009) 15:1558–65. doi: 10.1158/1078-...
BRCA Gene Mutations Associated With Increased Prostate Cancer RiskCharles Richardson
Professor Marc Tischkowitz from the Department of Medical Genetics at the University of Cambridge added, "The link between BRCA2 andprostate cancerand pancreatic cancer is now much clearer, thanks to the data we've analyzed. We have also identified a potential link with stomach cancer, but this...
[4] K. N. Chi et al. Niraparib plus abiraterone acetate with prednisone in patients with metastatic castration-resistant prostate cancer and homologous recombination repair gene alterations: second interim analysis of the randomized phase III MAGNITUDE trial. Ann Oncol 2023 Sep;34(9):772-782. ...
The U.S. Food and Drug Administration today authorized the Personal Genome Service Genetic Health Risk (GHR) Report for BRCA1/BRCA2 (Selected Variants). It is the first direct-to-consumer (DTC) test to report on three specific BRCA1/BRCA2 breast cancer gene mutations that are most common ...
Common genetic variation at PTEN and risk of sporadic breast and prostate cancer. Thus, PTEN serves as a candidate susceptibility gene for both breast and prostate cancer risk. Whether common inherited variation (either coding or non... Haiman,A C. - Cancer epidemiology, biomarkers & prevention ...
[4] K. N. Chi et al. Niraparib plus abiraterone acetate with prednisone in patients with metastatic castration-resistant prostate cancer and homologous recombination repair gene alterations: second interim ysis of the randomized phase III MAGNITUDE trial. Ann Oncol 2023 Sep;34(9):772-782. ...
乳腺癌易感基因(breast cancer susceptibility gene,BRCA)是重要的抑癌基因,包括BRCA1和BRCA2。BRCA1/2基因突变分为胚系突变和体细胞突变:BRCA1/2基因胚系突变起源于生殖细胞,显著增加乳腺癌、卵巢癌以及其他相关肿瘤的发病风险;BRCA1/2基因的体细胞突变仅存在于肿瘤细胞中。BRCA1/2基因变异状态在相关肿瘤(卵巢癌、...
We have also identified a potential link with stomach cancer, but this is based on small numbers and needs further study. Our data suggests that there is no strong link between BRCA2 and melanoma, which may provide greater clarity to BRCA2 gene carriers. "Overall, the results will add to ...