BRCA Gene Mutations Associated With Increased Prostate Cancer RiskCharles Richardson
BRCA1和BRCA2是乳腺癌易感基因(breast cancer susceptibility gene,BRCA),是重要的抑癌基因,其编码产物参与DNA损伤同源性重组修复(homologous recombination repair)。同源重组缺陷(homologous recombination deficiency,HRD)可以由BRCA1/2基因突变导致,使得基因组不稳定...
Professor Marc Tischkowitz from the Department of Medical Genetics at the University of Cambridge added, "The link between BRCA2 andprostate cancerand pancreatic cancer is now much clearer, thanks to the data we've analyzed. We have also identified a potential link with stomach cancer, but this...
Common genetic variation at PTEN and risk of sporadic breast and prostate cancer. Thus, PTEN serves as a candidate susceptibility gene for both breast and prostate cancer risk. Whether common inherited variation (either coding or non... Haiman,A C. - Cancer epidemiology, biomarkers & prevention ...
6.Schayek H, Haugk K, Sun S, True LD, Plymate SR, Werner H. Tumor Suppressor BRCA1 is Expressed in Prostate Cancer and Control IGF1-R Gene Transcription in an Androgen Receptor-Dependent Manner. Clin Cancer Res (2009) 15:1558–65. doi: 10.1158/1078-...
These PCa risk estimates will assist in guiding clinical management. The study-level subgroup analyses indicate that risks may be modified by age and ethnicity, and forBRCA2carriers by PV location within the gene, which may guide future risk-estimation studies. ...
(96.68%: 30/31) with advanced/metastatic breast cancer. In one Japanese male patient with advanced/metastatic breast cancer, a gene (ATM) belonging to the homologues recombination gene family with germline pathogenic variants (gPVs) was detected. Pathological diagnosis of resected tissue obtained ...
Common variation in the BRCA1 gene and prostate cancer risk. Cancer Epidemiol Biomark Prev 2007; 16: 1510–1516. Article CAS Google Scholar Giovannucci E, Ascherio A, Rimm EB, Stampfer M, Colditz G, Willett W . Intake of carotenoids and retinol in relation to risk of prostate cancer. ...
BRCA Gene and Preventive Cancer Surgery by Jeffrey Dach MD Angelina Jolie’s story in a New York Times Op Ed revealed the celebrity underwent not only a bilateral prophylactic mastectomy about two years ago, but also more recently, a bilateral oophorectomy (removal of the ovaries). (1) ...
[4] K. N. Chi et al. Niraparib plus abiraterone acetate with prednisone in patients with metastatic castration-resistant prostate cancer and homologous recombination repair gene alterations: second interim analysis of the randomized phase III MAGNITUDE trial. Ann Oncol 2023 Sep;34(9):772-782. ...