2、brca2 前列腺癌doi:10.14033/ki.cfmr.2019.30.081 a 1674-6805(2019)30-0-03abstract family history is one of the risk factors for prostate cancer, and breast cancer susceptibility gene 2 (brca2) is a proven genetic risk factor for prostate cancer. although the role of brca2 and brca1 ...
The failure to identify highly penetrant genes in hereditary prostate cancer may result from the fact that multiple genes with a small to moderate effect are involved. Aim o f the study is to evaluate the epidemiological features and BRCA2 gene mutation variations in hereditary prostate cancer in...
These PCa risk estimates will assist in guiding clinical management. The study-level subgroup analyses indicate that risks may be modified by age and ethnicity, and forBRCA2carriers by PV location within the gene, which may guide future risk-estimation studies. Similar content being viewed by othe...
BRCA2 基因 乳腺癌易感基因 2(Breast Cancer susceptibility gene 2, BRCA2)位于第 13 号染色体 13q12位置,有 27 个外显子,编码 3418 个氨基酸残基组成的蛋白质,是参与DNA损伤修复的抑癌基因。BRCA2 蛋白主要参与 DNA 双链损伤修复中的同源重组修复。在由RA...
"These data will help to optimize medical care in male BRCA1 and BRCA2 PV carriers," Dr. Ottini said. "In particular, screening and surveillance programs in men with BRCA1 and BRCA2 PVs should be tailored in light of these gene-specific cancer phenotype differences." ...
We found that carriers of BRCA2 mutations have a high risk of developing prostate cancer, particularly more aggressive prostate cancer, and that this risk varies by family history of prostate cancer and the location of the mutation within the gene....
prostate cancer, pancreatic cancer, and breast cancer in males. There has also been a rapid expansion of US Food and Drug Administration–approved targeted cancer therapies, including poly ADP ribose polymerase (PARP) inhibitors, for breast, pancreatic, and prostate cancers associated withBRCA1/2PVs...
摘要: Dear Editor,Here,we report the association of mutations in the prostate cancer cluster region(PCCR;c.7914 to 3')and non-PCCR(5'to c.7914)in breast cancer susceptibility gene 2(BRCA2)with prostate cancer(PCa)risk at the population level in Caucasian and Chinese cohorts.关键词:...
BRCA1和BRCA2是乳腺癌易感基因(breast cancer susceptibility gene,BRCA),是重要的抑癌基因,其编码产物参与DNA损伤同源性重组修复(homologous recombination repair)。同源重组缺陷(homologous recombination deficiency,HRD)可以由BRCA1/2基因突变导致,使得基因组不稳定...
[5] PRITCHARD C C, MATEO J, WALSH M F等. Inherited DNA-repair gene mutations in men with metastatic prostate cancer[J]. New England Journal of Medicine, Mass Medical Soc, 2016, 375(5): 443–453. [6] 韦煜, 吴俊龙, 顾伟杰. 中国前列腺癌患者 BRCA1/2 及 ATM 基因的胚系突变研究[J]. ...