[6] Fu F, Zhang D, Hu L, et al. Association between 15 known or potential breast cancer susceptibility genes and breast cancer risks in Chinese women[J]. Cancer Biol Med, 2021:253-262. [7] Yao L, Sun J, ...
Because bothBRCA1andBRCA2are autosomal genes, they can be carried and transmitted by men in the affected families.BRCA2, which localizes tochromosome 13, confers risks for breast and ovarian cancer in women similar to those conferred byBRCA1; unlikeBRCA1,BRCA2is associated with an increased ri...
⑵在BRCA1/2胚系突变患者中,通过多元logistic回归分析评估以下因素是否影响第二原发肿瘤的发生:年龄、是否绝经、肿瘤级别、肿瘤大小、阳性淋巴结数目、手术方式、分子分型(复旦四分型)、以及是否接受术后放疗。模型构建代码主体如下:“glm(Recur...
Among 84 breast cancer patients with genetic high risks, the carry mutation rate was 40.5% (34/84) and the pathogenic mutation rate was 15.4 (13/84) . Among 44 sporadic cases, the carry mutation rate was 9% (4/44) . The pathogenic mutation rate was 6.8% (3/44) . Breast cancer ...
One study found that the majority of females with a BRCA2 mutation have ER-positive and human epidermal receptor 2 (HER2)-negative BC [4]. Among sporadic BC, ER-positive BC are often characterized by late age of onset, low pathological grade, and low rate of lymph node metastasis and ...
This cohort study estimates age-specific risks of breast, ovarian, and contralateral breast cancer among carriers of BRCA1 and BRCA2 mutations and
Tamoxifenis a drug that binds to estrogen receptors and blocks their effects in the breasts. For this reason, tamoxifen is used for both the treatment and prevention of estrogen receptor-positive breast tumors. Multiple studies have associated the use of tamoxifen and similar drugs with a reduced...
Grann, VR, Panageas, KS, Whang, W, Antman, KH, Neugut, AI (1998) Decision analysis of prophylactic mastectomy and oophorectomy in BRCA1-positive and BRCA2-positive patients. J Clin Oncol 16: pp. 979-985Grann VR, Panageas KS, Whang W, Antman KH, Neugut AI. Decision analysis of ...
represent the mean ± SD of four independent experiments. (ns, not significant).dFrequency of mCherry positive cells in cells transfected with the promoter-less donor plasmid (AAVS1-2A-mCherry) without (−TALEN) (open circles) or with (+TALEN) nucleases (filled circles). The error ...
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutationsdetected in case Series unselected for family history: a combined analysis of 22 studies[J].Am J Hum Genet, 2003, 72(5):1117⁃1130. [9] Chen S, Parmigiani G. Meta⁃analysis of BRCA1 and BRCA2 ...