International Journal of Cancer 81(5): 839-843 1999 ISSN/ISBN:0020-7136 10328242 10.1002/(sici)1097-0215(19990531)81:5<839::aid-ijc28>3.0.co;2-v 003367405 Article emailed within 0-6 h Payments are secure & encrypted Abstract
D. et al. Disruption of the expected positive correlation between breast tumor size and lymph node status in BRCA1-related breast carcinoma. Cancer 98, 1569–1577 (2003). PubMed Google Scholar Goffin, J. R. et al. Impact of germline BRCA1 mutations and overexpression of p53 on prognosis...
Additional file1: Table S1; Tables1and2show the cohort size, inclusion criteria, andBRCApathogenic point mutations, LGR(s) and recurrent mutations detected in cohorts A, B and C, respectively. Additional file1: Table S1 show that in hereditary BC, 118 different BRCA point mutations were detect...
There is a lack of data regarding the prevalence ofBRCA1/2among female breast cancer patients in India.Methods:This prospective observational study included consecutive patients with breast cancer in females, registered at All India Institute of Medical Sciences (AIIMS), New Delhi, India between the...
BRCA2, like BRCA1, normally functions as a DNA repair gene, and in effect, a tumor suppressor gene Chromosome 13q12-13 III. Epidemiology Responsible for a third of hereditary Breast Cancer Affects Male as well as Female carriers of the genetic mutation IV. Associated Conditions Ovarian Cance...
Inherited mutation in BRCA2 increases the risk of female breast cancer by 69% and ovarian cancer by 17%11. The risk of developing other types of cancers, such as fallopian tube cancer12, peritoneal cancer13, pancreatic cancer, and prostate cancer14, is also increased in BRCA2 mutation carrier...
Cancer Risk Associated to BRCA Mutations Female breast and ovarian cancers are clearly the dominant cancers associated with BRCA1 and BRCA2 genes mutations. About 55%- 65% of women with BRCA1 mutation and around 50% of women with BRCA2 mutation will develop breast cancer by age 70 years (2...
Germline mutations in this gene confer a significantly increased risk for both male and female breast cancer, ovarian cancer, fallopian tube carcinoma, uveal tract and skin melanoma, and pancreatic, biliary tract, and prostatic carcinoma. The prevalence of mutations in this gene in the general ...
A 40-year-old Emirati female presented with unilateral breast cancer. The initial biopsy revealed invasive ductal carcinoma (IDC), and it was estrogen (ER) and progesterone receptor (PR) positive and human epidermal growth factor receptor 2 (HER2) negative. Although there was no reported family ...
mechanism can be under separate regulatory control, allowing HSF2BP to serve as a versatile and potent agent increasing the local concentration and/or modifying the oligomerization state of BRCA2. This can play a positive role in some contexts and be detrimental in others. For example, we ...