The immunophenotypic predictive profile of BRCA1 -associated cancers including major predictive markers, i.e., PARP-1, EGFR, c-kit, HER-2, and steroid hormones (ER/PR) that may have therapeutic relevance has not yet been reported in a comprehensive study. Using immunohistochemistry, we ...
Germline variants in BRCA1 and BRCA2 (also known as pathogenic or likely pathogenic variants, referred to here as BRCA1/2 PVs) are well known to significantly increase the risk of breast and ovarian cancers in female carriers, and knowledge of BRCA1/2 PVs informs established cancer screening ...
BRCA1-mutated tumours also show a significantly higher degree of genomic instability than sporadic breast cancers (Tirkkonen et al, 1997), which is likely because of the functions of BRCA1 in cell-cycle regulation and DNA repair (see below). Mutations in BRCA1 are not confined to certain ...
Summary Germline mutations of BRCA1 predispose women to breast and ovarian cancers. However, the downstream mediators of BRCA1 function in tumor suppression remain elusive. We found that human BRCA1-associated breast cancers have lower levels of SIRT1 than their normal controls. We further demonstrat...
Stumbling Blocks on the Path to Personalized Medicine in Breast Cancer: The Case of PARP Inhibitors for BRCA1/2 -Associated Cancers Stumbling blocks on the path to personalized medicine in breast cancer: the case of PARP inhibitors for BRCA1/2-associated cancers. Cancer Discov. 2011;... J ...
Mutations in the BRCAI-Associated RING Domain (BARD1) Gene in Primary Breast, Ovarian and Uterine Cancers Germline alterations of BRCA1 result in susceptibility to breast and ovarian cancer. The protein encoded by BRCA1 interacts in vivo with the BRCA1-associat... Thai,T. - 《Human Molecular...
In addition, VEGF expression levels have been reported to be increased by estrogen in breast cancer cells [5] and isolated endometrial cells [6], [7], which supports the notion that VEGF plays a significant role in the development of breast and other hormone-related cancers. Moreover, high ...
Women who carry a pathogenic mutation in the breast cancer susceptibility genes BRCA1 or BRCA2 ( BRCA ) have markedly increased risks of developing breast and ovarian cancers during their lifetime. It has been estimated that their breast... U Hamann - 《Journal of the Medical Sciences》 被引...
Mutations in the BRCAI-Associated RING Domain (BARD1) Gene in Primary Breast, Ovarian and Uterine Cancers Germline alterations of BRCA1 result in susceptibility to breast and ovarian cancer. The protein encoded by BRCA1 interacts in vivo with the BRCA1-associat... Thai,T. - 《Human Molecular...
PARP inhibitors in BRCA1-/BRCA2-associated and triple-negative breast cancers 来自 掌桥科研 喜欢 0 阅读量: 29 作者:J Stebbing,P Ellis,A Tutt 摘要: Stebbing J, Ellis P, Tutt A.关键词:breast cancer BRCA PARP inhibitor triple negative ...