DNA Analysis Core Facility at the University of Texas MD Anderson Cancer (CA016672) for their technical support. We thank Sarah Bronson and Ann Sutton at the Research Medical Library for Editing Services. We also thank
Full size image BRCA1/2-mutated cancers BRCA1-mutated tumors include all tumors which exhibit a pathogenic mutation and not a Variant of Unknown Significance (VUS) in the BRCA1 gene [39]. Mutations in BRCA1 gene are detected in different cancers, such as in BrCa (about 5% to 10% of ...
Relevant studies were searched in PubMed, EMBASE and China National Knowledge Infrastructure (CNKI) databases using the following terms: “BRCA1 or Breast cancer susceptibility gene 1 or Breast cancer 1” and “NSCLC or non-small-cell lung cancer”. The last research time was December 10, 2012...
(b) Western blot demonstrating that BRCA1- mutant (red) cell lines express full-length 53BP1 protein, but not BRCA1. (c) Quantification of 53BP1 protein expression for select cell lines. Individual normalized band intensity values in arbitrary units (A.U.) from three independent experiments ...
Cancers were confirmed after central medical record review. Blood samples, which were collected at entry, were analyzed for BRCA1 promoter methylation by massive parallel sequencing. The study was performed in the Mohn Cancer Research Laboratory (Bergen, Norway) between 2019 and 2022. Main Outcomes ...
Medical record review was carried out by 3 clinicians (K.M., D.M.L., and M.F.M.) independently and then jointly to determine the cancer diagnosis and cause of death (eTable 3 in the Supplement). Statistical Analysis Data were summarized using means and ranges for continuous variables as...
©Emmanuel Osei Nkansah et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Cite this article: Emmanuel Osei Nkansah1, John Ahenkorah1, Kevin Adutwum-Ofosu1, Raymond Lovelace Adjei2, ...
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 316, 1194–1198 (2007). Article CAS Google Scholar Doil, C. et al. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell 136, 435–...
In this situation, no DSBs are created (C). (D) Possible pathway resolving lagging strand blockage. Downstream re-initiation of lagging-strand synthesis after blockage leaves a gap on the lagging strand which can be repaired by HR. Full size image Broken replication fork-stimulated HR may be ...
Full size table Fig. 2: PREDICT calibration in CIMBA data. Point estimates and pooled 95% confidence intervals of observed mortality against expected mortality for a BRCA1 carriers with ER-negative breast cancer, and b BRCA2 carriers with ER-positive breast cancer. Full size image In summary,...